Center for Clinical Academia, Graduate School of Public Health, Luke's International University, 5th Floor 3-6-2, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Int J Environ Res Public Health. 2021 Jun 21;18(12):6653. doi: 10.3390/ijerph18126653.
Growing evidence suggests that PM is associated with diabetes mellitus (DM). Although DM is a major public health concern, there has not yet been a study of this association in Japan. We used health examination data from 66,885 individuals in Tokyo, Japan 2005-2019. Cox proportional hazards models were used to evaluate an association between annual exposure to PM and glycated hemoglobin A (HbA), or fasting plasma glucose (FPG). An increase of 1 μg/m in the annual average of PM concentration was associated (HR = 1.029; 95% CI = 1.004-1.055) with an increase in diabetes (incident + prevalent). For incident DM, a greater PM level was associated with more DM (HR = 1.029; 95% CI, 1.003-1.055). Compared to HbA, FPG showed a stronger association with the annual exposure to PM (HR = 1.065; 95% CI, 1.040-1.091). We found that greater exposure to PM in the long-term was associated with an increased risk of diabetes, and that the magnitude of association became stronger as the exposure duration increased. Omorogieva Ojo.
越来越多的证据表明，PM 与糖尿病（DM）有关。虽然 DM 是一个主要的公共卫生问题，但在日本还没有研究过这种关联。我们使用了 2005 年至 2019 年来自日本东京的 66885 个人的健康检查数据。我们使用 Cox 比例风险模型来评估每年暴露于 PM 与糖化血红蛋白 A（HbA）或空腹血浆葡萄糖（FPG）之间的关联。PM 浓度年平均值每增加 1μg/m3，与糖尿病（新发+现患）的增加相关（HR=1.029；95%CI=1.004-1.055）。对于新发 DM，更高的 PM 水平与更多的 DM 相关（HR=1.029；95%CI，1.003-1.055）。与 HbA 相比，FPG 与 PM 的年暴露量显示出更强的关联（HR=1.065；95%CI，1.040-1.091）。我们发现，长期暴露于 PM 与糖尿病风险增加有关，而且暴露时间越长，关联的幅度就越强。
