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犬垂体依赖性肾上腺皮质功能亢进症药物治疗的另一种方案。

An alternative protocol for the medical management of canine pituitary-dependent hyperadrenocorticism.

作者信息

Rijnberk A, Belshaw B E

机构信息

Small Animal Clinic, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.

出版信息

Vet Rec. 1988 May 14;122(20):486-8. doi: 10.1136/vr.122.20.486.

DOI:10.1136/vr.122.20.486
PMID:3420770
Abstract

As an alternative to the o,p'-DDD treatment aimed at the selective destruction of the adrenal cortices, the authors have introduced a protocol aimed at the complete destruction of the adrenal cortices. It consists of a longer period of daily treatment with o,p'-DDD and lifelong substitution for primary hypoadrenocorticism. The results obtained in 41 dogs, with a minimum follow-up period of one year, indicate that this approach has advantages over lifelong maintenance therapy with o,p'-DDD.

摘要

作为旨在选择性破坏肾上腺皮质的邻,对'-滴滴滴治疗的替代方法,作者引入了一种旨在完全破坏肾上腺皮质的方案。该方案包括更长时间的每日邻,对'-滴滴滴治疗以及对原发性肾上腺皮质功能减退的终身替代治疗。在41只犬中获得的结果(最短随访期为一年)表明,这种方法比使用邻,对'-滴滴滴的终身维持治疗具有优势。

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An alternative protocol for the medical management of canine pituitary-dependent hyperadrenocorticism.犬垂体依赖性肾上腺皮质功能亢进症药物治疗的另一种方案。
Vet Rec. 1988 May 14;122(20):486-8. doi: 10.1136/vr.122.20.486.
2
Mitotane (o,p'-DDD) treatment of 200 dogs with pituitary-dependent hyperadrenocorticism.米托坦(邻,对'-滴滴滴)治疗200只垂体依赖性肾上腺皮质功能亢进犬。
J Vet Intern Med. 1991 May-Jun;5(3):182-90. doi: 10.1111/j.1939-1676.1991.tb00945.x.
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Medical treatment of pituitary-dependent hyperadrenocorticism. Mitotane.垂体依赖性肾上腺皮质增生症的医学治疗。米托坦。
Vet Clin North Am Small Anim Pract. 1997 Mar;27(2):255-72. doi: 10.1016/s0195-5616(97)50030-1.
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Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma.一只患有垂体依赖性肾上腺皮质功能亢进和嗜铬细胞瘤的犬对米托坦(邻,对'-滴滴滴)耐药。
Aust Vet J. 1998 Feb;76(2):101-3. doi: 10.1111/j.1751-0813.1998.tb14536.x.
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o,p'-DDD (mitotane) treatment of canine pituitary-dependent hyperadrenocorticism.
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Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane.垂体依赖性肾上腺皮质增生症的药物治疗:米托坦与曲洛司坦的比较
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Use of the urine cortisol-to-creatinine ratio for monitoring dogs with pituitary-dependent hyperadrenocorticism during induction treatment with mitotane (o,p'-DDD).在使用米托坦(邻,对'-滴滴滴)进行诱导治疗期间,利用尿皮质醇与肌酐比值监测垂体依赖性肾上腺皮质功能亢进症犬。
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Results of non-selective adrenocorticolysis by o,p'-DDD in 129 dogs with pituitary-dependent hyperadrenocorticism.129只垂体依赖性肾上腺皮质功能亢进犬使用邻对滴滴滴进行非选择性肾上腺皮质溶解的结果。
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Corticoid production by four dogs with hyperfunctioning adrenocortical tumours during treatment with mitotane (o,p'-DDD).
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