Tsyplakov D E, Ziganshina L E
Vopr Onkol. 1988;34(8):932-6.
Morphologic, histochemical, biochemical and morphometric procedures were employed for examination of resected regional lymph nodes obtained from 70 patients suffering various malignancies. The important role of blood microcirculation bed alterations in cancer dissemination was established, the said disorders being as follows: decreased functional activity of the vascular wall and its increased permeability matched by intravascular blood coagulation and extravascular deposition of large amounts of fibrin in the lymph node tissue. Those changes were largely determined by lymph node mast cell reaction and levels of histamine and serotonin in the lymph node tissue. They preceded lymph node involvement.
采用形态学、组织化学、生物化学和形态测量学方法，对70例患有各种恶性肿瘤患者切除的区域淋巴结进行检查。确定了血液微循环床改变在癌症扩散中的重要作用，这些改变如下：血管壁功能活性降低及其通透性增加，同时伴有血管内血液凝固和大量纤维蛋白在淋巴结组织中的血管外沉积。这些变化在很大程度上由淋巴结肥大细胞反应以及淋巴结组织中组胺和血清素水平决定。它们先于淋巴结受累出现。
