[The role of microcirculatory factors in cancer metastasis].

Morphologic, histochemical, biochemical and morphometric procedures were employed for examination of resected regional lymph nodes obtained from 70 patients suffering various malignancies. The important role of blood microcirculation bed alterations in cancer dissemination was established, the said disorders being as follows: decreased functional activity of the vascular wall and its increased permeability matched by intravascular blood coagulation and extravascular deposition of large amounts of fibrin in the lymph node tissue. Those changes were largely determined by lymph node mast cell reaction and levels of histamine and serotonin in the lymph node tissue. They preceded lymph node involvement.