Lazear E J, Louie S C
Cancer Lett. 1978 Jan;4(1):21-5. doi: 10.1016/s0304-3835(78)93137-3.
The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme factor. When hydrochloride salts of the parent compounds were made to improve their stability for animal feeding experiments, the mutagenicity for the Salmonella tester strains was reduced except for 3,3'-dimethylbenzidine. Animal feeding trials in mice are underway to determine the dose response relationship of tumor incidence and molecular configuration.
使用鼠伤寒沙门氏菌TA - 98和TA - 100以及小鼠肝脏酶制剂对联苯胺类似物进行致突变性检测。只有4 - 氨基联苯产生了移码突变和碱基对置换突变，而3,3'-二氯联苯胺是唯一一种在没有哺乳动物酶因子的情况下具有致突变性的化合物。为了提高母体化合物的稳定性以进行动物喂养实验而制备其盐酸盐时，除3,3'-二甲基联苯胺外，对沙门氏菌测试菌株的致突变性均降低。正在对小鼠进行动物喂养试验，以确定肿瘤发生率与分子构型之间的剂量反应关系。
