Center for Research on Human Nutrition Ile-de-France (CRNH IdF), Nutrition Department, Institute of Cardiometabolism and Nutrition (ICAN), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière University Hospital, Sorbonne Université, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
NutriOmics Team, INSERM UMRS U1166, Sorbonne Université, 75006 Paris, France.
Nutrients. 2021 Jun 30;13(7):2276. doi: 10.3390/nu13072276.
: SARS-CoV2 infection is associated with an increased risk of malnutrition. Although there are numerous screening and nutritional management protocols for malnutrition, only few studies have reported nutritional evolution after COVID-19. The objectives of this study were to describe the evolution of nutritional parameters between admission and 30 days after hospital discharge, and to determine predictive factors of poor nutritional outcome after recovery in adult COVID-19 patients. : In this observational longitudinal study, we report findings after discharge in 91 out of 114 patients initially admitted for COVID-19 who received early nutritional management. Nutritional status was defined using GLIM criteria and compared between admission and day 30 after discharge. Baseline predictors of nutritional status at day 30 were assessed using logistic regression. : Thirty days after discharge, 28.6% of patients hospitalized for COVID-19 were malnourished, compared to 42.3% at admission. Half of malnourished patients (53%) at admission recovered a normal nutritional status after discharge. Weight trajectories were heterogeneous and differed if patients had been transferred to an intensive care unit (ICU) during hospitalization ( = 0.025). High oxygen requirement during hospitalization (invasive ventilation = 0.016 (OR 8.3 [1.6-61.2]) and/or oxygen therapy over 5 L/min = 0.021 (OR 3.2 [1.2-8.9]) were strong predictors of malnutrition one month after discharge. : With early nutritional management, most patients hospitalized for COVID-19 improved nutritional parameters after discharge. These findings emphasize the importance of nutritional care in COVID-19 patients hospitalized in medicine departments, especially in those transferred from ICU.
SARS-CoV2 感染与营养不良风险增加有关。尽管有许多用于营养不良的筛查和营养管理方案,但只有少数研究报告了 COVID-19 后的营养演变。本研究的目的是描述入院至出院后 30 天营养参数的演变,并确定 COVID-19 成年患者康复后营养不良结局的预测因素。
在这项观察性纵向研究中,我们报告了最初因 COVID-19 入院并接受早期营养管理的 114 名患者中出院后 91 名患者的发现。使用 GLIM 标准定义营养状况,并在入院时和出院后第 30 天进行比较。使用逻辑回归评估第 30 天营养状况的基线预测因素。
出院后 30 天,91 名 COVID-19 住院患者中有 28.6%存在营养不良,而入院时为 42.3%。入院时营养不良的患者中有一半(53%)在出院后恢复正常营养状态。体重轨迹存在异质性,如果患者在住院期间被转至重症监护病房(ICU)则有所不同( = 0.025)。住院期间高氧需求(有创通气 = 0.016(OR 8.3 [1.6-61.2])和/或氧疗超过 5 L/min = 0.021(OR 3.2 [1.2-8.9])是出院后一个月营养不良的强烈预测因素。
通过早期营养管理,大多数因 COVID-19 住院的患者在出院后改善了营养参数。这些发现强调了在医学科住院的 COVID-19 患者中进行营养护理的重要性,特别是在从 ICU 转来的患者中。