Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
Medicina (Kaunas). 2021 Jun 29;57(7):668. doi: 10.3390/medicina57070668.
Obstructive sleep apnea (OSA) is closely associated with insulin resistance (IR) and is an independent risk factor for incident type 2 diabetes mellitus (T2DM). Most studies evaluate the correlation between OSA and IR in only obese or T2DM patients. Therefore, we tried to investigate the effect of OSA on metabolic syndrome and IR in the general healthy male population. 184 subjects who visited a preventive health examination program were recruited for this study. All subjects received overnight polysomnography by a portable device (Watch-PAT 200). We examined several metabolic parameters and a homeostasis model of assessment for insulin resistance index (HOMA-IR). The subjects were divided into three groups by AHI (Apnea-hyponea index): normal group (AHI < 5), mild OSA group (5 ≤ AHI < 15), and moderate-severe OSA group (AHI ≥ 15). They were also divided into two groups according to minimum oxygen saturation: low group, Min-SpO2 < 88%; and high group, Min-SpO2 ≥ 88%. Parameters of metabolic syndrome, including waist circumference, systolic and diastolic blood pressure, triglyceride, and high-density lipoprotein cholesterol showed significant differences among the AHI groups. Furthermore, HOMA-IR showed significant differences among the AHI groups. Those parameters, including metabolic syndrome and HOMA-IR, also showed differences between Min-SpO2 groups. In summary, this study helps confirm that AHI is associated with HOMA-IR in the general male population. Furthermore, the severity of AHI correlated with the parameters of metabolic syndrome. Therefore, AHI might be an indicator for evaluating both T2DM and metabolic syndrome, even in the general male population.
阻塞性睡眠呼吸暂停（OSA）与胰岛素抵抗（IR）密切相关，是 2 型糖尿病（T2DM）发病的独立危险因素。大多数研究仅在肥胖或 T2DM 患者中评估 OSA 与 IR 之间的相关性。因此，我们试图研究 OSA 对一般健康男性人群代谢综合征和 IR 的影响。
本研究共纳入 184 名接受体检的男性。所有患者均接受便携式设备（Watch-PAT 200）进行整夜多导睡眠监测。我们检测了多种代谢参数和胰岛素抵抗指数（HOMA-IR）的稳态模型评估。根据 AHI（呼吸暂停-低通气指数）将患者分为三组：正常组（AHI＜5）、轻度 OSA 组（5≤AHI＜15）和中重度 OSA 组（AHI≥15）。根据最低血氧饱和度将患者分为两组：低组（Min-SpO2＜88%）和高组（Min-SpO2≥88%）。
代谢综合征的参数，包括腰围、收缩压和舒张压、甘油三酯和高密度脂蛋白胆固醇，在 AHI 组之间存在显著差异。此外，AHI 组之间的 HOMA-IR 也存在显著差异。这些参数，包括代谢综合征和 HOMA-IR，在 Min-SpO2 组之间也存在差异。
综上所述，本研究有助于证实 AHI 与一般男性人群的 HOMA-IR 相关。此外，AHI 的严重程度与代谢综合征的参数相关。因此，即使在一般男性人群中，AHI 也可能是评估 T2DM 和代谢综合征的指标。
