前列腺癌易感性。
Prostate Cancer Predisposition.
机构信息
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Marburg 134, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Marburg 115, 600 North Wolfe Street, Baltimore, MD 21287, USA.
出版信息
Urol Clin North Am. 2021 Aug;48(3):283-296. doi: 10.1016/j.ucl.2021.03.001. Epub 2021 Jun 12.
The identification and characterization of alterations in prostate cancer (PCa)-predisposing genes can help to inform screening strategies in undiagnosed men and treatment options in men in both the clinically localized and in the metastatic setting. This review provides an overview of the genetic basis underlying hereditary predisposition to PCa, the current role of genetics and PCa risk assessment, and how genetic risk factors affect aggressiveness and lethality of PCa.
前列腺癌（PCa）易感基因的鉴定和特征描述有助于为未确诊男性提供筛查策略，并为临床局限性和转移性疾病男性提供治疗选择。本文综述了遗传性 PCa 易感性的遗传基础、遗传与 PCa 风险评估的当前作用，以及遗传风险因素如何影响 PCa 的侵袭性和致死性。
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