Familial Cancer Program, The University of Vermont Medical Center, Main Campus, East Pavilion, Level 2, 111 Colchester Avenue, Burlington, VT 05401, USA.
Sidney Kimmel Cancer Center, Clinical Cancer Genetics, 1100 Walnut Street, Suite 602, Philadelphia, PA 19107, USA.
Urol Clin North Am. 2021 Aug;48(3):323-337. doi: 10.1016/j.ucl.2021.03.004. Epub 2021 Jun 16.
Germline genetic testing is becoming more prevalent in urology clinics because of precision medicine for prostate cancer treatment. Genetic testing results can also influence cancer screening discussions for patients and/or their families. An important part of germline genetic testing is genetic counseling. This article provides an overview of the historical aspects of genetic counseling, discusses the components needed to provide proper genetic counseling, summarizes genes related to hereditary prostate cancer risk, and reviews genetic privacy and genetic discrimination concerns related to germline genetic testing.
由于前列腺癌治疗的精准医学，生殖系基因检测在泌尿科诊所越来越普遍。基因检测结果也会影响患者和/或其家属的癌症筛查讨论。生殖系基因检测的一个重要部分是遗传咨询。本文概述了遗传咨询的历史方面，讨论了提供适当遗传咨询所需的组成部分，总结了与遗传性前列腺癌风险相关的基因，并回顾了与生殖系基因检测相关的遗传隐私和遗传歧视问题。
