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由......引起的动物源性眼部盘尾丝虫病。

Zoonotic Ocular Onchocercosis by .

机构信息

Laboratory of Helminthology, Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

出版信息

Yale J Biol Med. 2021 Jun 30;94(2):331-341. eCollection 2021 Jun.

Abstract

The parasitic filarioid causes ocular disease characterized by conjunctivitis and nodular lesions. This nematode was first described in 1967 in a wolf from Georgia, and since then cases of infection from dogs and cats with ocular onchocercosis and sporadically from humans also with subcutaneous and cervical lesions caused by have been reported from the Middle East, Europe, and North America. Due to its zoonotic potential, this parasitic infection has gained attention in the past 20 years. Phylogenetic studies have highlighted the recent divergence of from other spp. and the importance of domestication in the evolutionary history of this worm. Moreover, the finding of an genotype associated with subclinical and mild infection in the Iberian Peninsula, raises important questions about the pathogenicity of this presently enigmatic parasite.

摘要

寄生的丝虫引起以结膜炎和结节病变为特征的眼部疾病。这种线虫于 1967 年在佐治亚州的一只狼身上首次被描述,此后,来自中东、欧洲和北美的狗和猫感染眼部盘尾丝虫病以及偶尔感染人类皮下和颈部病变的病例也有报道。由于其人畜共患的潜力,这种寄生虫感染在过去 20 年中引起了关注。系统发育研究突出了与其他旋尾线虫属不同的近期分化,以及在这种蠕虫的进化历史中驯化的重要性。此外,在伊比利亚半岛发现与亚临床和轻度感染相关的旋尾线虫基因型,引发了关于这种目前神秘寄生虫致病性的重要问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1d5/8223538/b800f68eb325/yjbm_94_2_331_g01.jpg

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