Coronary and skeletal muscle enzyme changes during a 14 km run.

Increasing coronary enzyme values have previously been demonstrated after physical exercise. In the present study serum values of aspartate aminotransferase (ASAT), lactate dehydrogenase (LDH), LDH isoenzymes, creatinine kinase (CK), and the myocardial-bound fraction of this enzyme (CK-MB) were measured in a random sample of healthy non-smoking, physically fit men before and immediately after a competitional 14 km run. All enzyme values increased during the run, ASAT by 7%, LDH by 25%, CK by 38%, and CK-MB by 53%. Measurement of LDH isoenzymes showed special increments of the non-cardiac fractions. However, absolute increments of the cardiac fractions of the LDH isoenzymes together with other serum enzyme elevations do not exclude a cardiac source of enzyme release during and following physical exercise.