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血管内皮生长因子在前列腺腺癌中的免疫表达

VEGF Immunoexpression in Prostate Adenocarcinoma.

作者信息

Pănuş Andrei, Simionescu Cristiana Eugenia, Drăgoescu Petru Octavian, Stepan Alex Emilian

机构信息

PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.

Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.

出版信息

Curr Health Sci J. 2021 Jan-Mar;47(1):89-95. doi: 10.12865/CHSJ.47.01.14. Epub 2021 Mar 31.

DOI:10.12865/CHSJ.47.01.14
PMID:34211753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8200605/
Abstract

Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions.

摘要

血管生成是肿瘤进展的一种基本生物分子机制，血管内皮生长因子（VEGF）是这一复杂过程的主要促进因子之一。在本研究中，我们分析了61例前列腺腺癌（PA）中VEGF-A的免疫表达情况，并将其与病变的预后参数相关联。在血清PSA值高于20ng/ml的PA、具有单纯复杂或混合生长模式的肿瘤以及高级别和晚期病变中，VEGF评分更高。所得结果表明VEGF参与前列腺血管生成，且该标志物对于识别侵袭性病变具有实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2066/8200605/f673ded8e3a3/CHSJ-47-01-89-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2066/8200605/8c9b65f2cf38/CHSJ-47-01-89-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2066/8200605/f673ded8e3a3/CHSJ-47-01-89-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2066/8200605/8c9b65f2cf38/CHSJ-47-01-89-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2066/8200605/f673ded8e3a3/CHSJ-47-01-89-fig2.jpg

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本文引用的文献

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Growth factors involve in cellular proliferation, differentiation and migration during prostate cancer metastasis.生长因子在前列腺癌转移过程中参与细胞增殖、分化和迁移。
Int J Cell Biol Physiol. 2019;2(1-2):1-13. Epub 2019 Oct 7.
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Cancer statistics, 2020.癌症统计数据，2020 年。
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Epidemiology of Prostate Cancer.前列腺癌流行病学
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Evaluation of VEGF and PEDF in prostate cancer: A preliminary study in serum and biopsies.前列腺癌中血管内皮生长因子（VEGF）和色素上皮衍生因子（PEDF）的评估：血清及活检组织的初步研究
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