Padhi Parikshit, Topalovski Margarita
Memorial Medical Center, Department of Hematology Oncology, 2530 S. Telshor Blvd, Las Cruces, NM 88011, USA.
Memorial Medical Center, Department of Pathology, 2540 S. Telshor Blvd, Las Cruces, NM 88011, USA.
Case Rep Obstet Gynecol. 2021 Jun 8;2021:5536675. doi: 10.1155/2021/5536675. eCollection 2021.
Benign metastasizing leiomyoma (BML) is a rare spindle cell neoplasm seen in middle-aged women who have a history of leiomyoma of the uterus. The most common sites of metastases are the lungs; however, other sites of spread have been documented. These tumors by definition have no malignant features on histology and tend to be estrogen and progesterone positive. We present a middle-aged woman who was incidentally found to have multiple pulmonary nodules and a mass on her sternum after she was involved in a motor vehicle accident. She had a history of uterine leiomyoma and had undergone a hysterectomy ten years prior to the accident. Biopsies were performed of the lung nodules and sternum mass and compared to her hysterectomy specimen, and they were identical, and hence, she was diagnosed with BML. Due to the growing tumor of her sternum, she was started on tamoxifen with stability of her tumors. These tumors, since they are benign, tend to have an indolent course. However, in the instances that treatment is warranted, options include surgery or antiestrogen therapy. We will be discussing the pathogenesis, histological findings, and treatment options of this rare condition. Our case is unique because BML in general do not tend to spread to multiple organs and tend to be limited to one site of disease.
良性转移性平滑肌瘤（BML）是一种罕见的梭形细胞瘤，见于有子宫平滑肌瘤病史的中年女性。最常见的转移部位是肺；然而，也有其他转移部位的记录。根据定义，这些肿瘤在组织学上没有恶性特征，且往往雌激素和孕激素呈阳性。我们报告一名中年女性，她在机动车事故后偶然发现有多个肺结节和胸骨肿块。她有子宫平滑肌瘤病史，事故发生前十年已行子宫切除术。对肺结节和胸骨肿块进行活检，并与她的子宫切除标本进行比较，结果相同，因此，她被诊断为BML。由于胸骨肿瘤不断生长，她开始服用他莫昔芬，肿瘤病情稳定。这些肿瘤由于是良性的，往往病程进展缓慢。然而，在需要治疗的情况下，治疗选择包括手术或抗雌激素治疗。我们将讨论这种罕见疾病的发病机制、组织学表现和治疗选择。我们的病例很独特，因为一般来说，BML不会倾向于扩散到多个器官，往往局限于一个疾病部位。
