Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
J Dermatol. 2021 Oct;48(10):1474-1481. doi: 10.1111/1346-8138.16035. Epub 2021 Jul 1.
Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.
甲纵向嵴伴有甲下裂片的甲真菌病与真菌性毛癣菌病一样，据报道对口服药物难治。我们评估了 10%依氟康唑溶液治疗甲纵向嵴的疗效。在之前的一项研究中，共有 223 名受试者入组，本研究对其中 82 名甲纵向嵴受试者进行了事后分析。从基线到最终评估，纵向嵴的混浊比值从 8.1 逐渐降低至 0.9。此外，在应用后的早期，纵向嵴消失率增加，最终评估时达到 81.7%。因此，10%依氟康唑溶液可作为甲纵向嵴的一线药物，这些嵴一直被认为对口服药物难治。
