影响输血依赖型β-地中海贫血（TDT）葡萄糖稳态的胰腺变化：简短综述。

The Pancreatic changes affecting glucose homeostasis in transfusion dependent β- thalassemia (TDT): a short review.

机构信息

Quisisana Hospital, Ferrara.

Department of Pediatrics, Division of Endocrinology, Hamad General Hospital, Doha, Qatar and Department of Pediatrics, Division of Endocrinology, Alexandria University Children's Hospital, Alexandria, Egypt.

出版信息

Acta Biomed. 2021 Jul 1;92(3):e2021232. doi: 10.23750/abm.v92i3.11685.

BACKGROUND

The natural history of the glycometabolic state in transfusion-dependent β-thalassemia (TDT) patients is characterized by a deterioration of glucose tolerance over time.

AIMS

This review depicts our current knowledges on the complex and multifacet pathophysiologic mechanisms implicated in the development of alteration of glucose homeostasis in patients with TDT.

SEARCH STRATEGY

A systematic search was done on December 2020 including Web of Science (ISI), Scopus, PubMed, Embase, and Scholar for papers published in the last 20 years. Moreover, we checked the reference lists of the relevant articles and previously performed reviews for additional pertinent studies. The personal experience on the care of patients with thalassemias is also reported.

CONCLUSION

A regular packed red blood cells (PRBCs) transfusion program, optimization of chelation therapy, and prevention and treatment of liver infections are critical to achieve adequate glucometabolic control in TDT patients. Many exciting opportunities remain for further research and therapeutic development.

背景

依赖输血的β-地中海贫血（TDT）患者的糖代谢状态的自然史特征是随着时间的推移葡萄糖耐量恶化。

目的

本文综述了我们目前对 TDT 患者葡萄糖稳态改变发展中涉及的复杂和多方面病理生理机制的认识。

检索策略

2020 年 12 月，我们在 Web of Science（ISI）、Scopus、PubMed、Embase 和 Scholar 上进行了系统检索，以查找过去 20 年发表的论文。此外，我们还检查了相关文章的参考文献列表和之前的综述，以寻找其他相关研究。还报告了在地中海贫血患者护理方面的个人经验。