胃蛋白酶原 I 和胃泌素 17 水平异常一例梅内特病。
Abnormal Levels of Pepsinogen I and Gastrin 17 in a case of Ménétrier Disease.
机构信息
Department of Medicine and Surgery, University of Parma.
Department of Medicine, ULSS7 Pedemontana, Hospital AltoVicentino, Santorso (VI).
出版信息
Acta Biomed. 2021 Jul 1;92(3):e2021207. doi: 10.23750/abm.v92i3.11592.
BACKGROUND AND AIM
We describe a case of Ménétrier disease, occurred in female patient.
METHODS
We decide to assess by non-invasive way (serum pepsinogens and gastrin 17) the secretory status of gastric mucosa, to confirm previous data of the literature, claiming high levels of both acid secretion and hypergastrinemia in this rare pathological condition.
RESULTS AND CONCLUSION
We find in the subject the highest values of pepsinogen 1 - a marker of acid secretion - never described in the literature to our knowledge: 1940 mcg/L, being normal values ranging from 30-160 mcg/L. Similarly, gastrin 17, produced 90% in the antrum and responsible for negative acid feedback, was very high: 139 pg/L, ranging normal values between 1-10 pg/L. (www.actabiomedica.it).
背景与目的
我们描述了一例女性梅内特rier 病病例。
方法
我们决定通过非侵入性方法（血清胃蛋白酶原和胃泌素 17）评估胃黏膜的分泌状态，以证实文献中先前提出的这一罕见病理状况下胃酸分泌和高胃泌素血症均升高的观点。
结果与结论
我们发现该患者的胃蛋白酶原 1（胃酸分泌的标志物）值最高，据我们所知，该值从未在文献中描述过：1940 mcg/L，正常值范围为 30-160 mcg/L。同样，胃泌素 17 也非常高，其 90%在胃窦中产生，负责负反馈抑制胃酸，正常值范围在 1-10 pg/L 之间。（www.actabiomedica.it）。
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