光催化苯乙烯与 CO 的碳羧化反应合成 γ-氨基丁酸酯。
Photocatalytic carbocarboxylation of styrenes with CO for the synthesis of γ-aminobutyric esters.
机构信息
Department of Chemistry, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Republic of Korea.
出版信息
Org Biomol Chem. 2021 Jul 21;19(28):6301-6312. doi: 10.1039/d1ob00866h.
Metal-free photoredox-catalyzed carbocarboxylation of various styrenes with carbon dioxide (CO2) and amines to obtain γ-aminobutyric ester derivatives has been developed (up to 91% yield, 36 examples). The radical anion of (2,3,4,6)-3-benzyl-2,4,5,6-tetra(9H-carbazol-9-yl)benzonitrile (4CzBnBN) possessing a high reduction potential (-1.72 V vs. saturated calomel electrode (SCE)) easily reduces both electron-donating and electron-withdrawing group-substituted styrenes.
发展了一种无金属的光氧化还原催化的各种苯乙烯与二氧化碳（CO2）和胺的碳羧化反应，以获得γ-氨基丁酸酯衍生物（高达 91%的产率，36 个例子）。（2,3,4,6）-3-苄基-2,4,5,6-四（9H-咔唑-9-基）苯腈（4CzBnBN）的负离子具有较高的还原电位（-1.72 V 对饱和甘汞电极（SCE）），容易还原供电子和吸电子基团取代的苯乙烯。
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