Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Ther Apher Dial. 2022 Apr;26(2):362-367. doi: 10.1111/1744-9987.13705. Epub 2021 Jul 13.
Anemia treatment is crucial in the management of dialyzed patients. Although Hb and serum ferritin levels are commonly used as indicators for treatment, these values change over time due to changes in policy, drugs for treating anemia, and target levels suggested by clinical guidelines. To clarify long-term changes in anemia-related parameters in Japan, we extracted annual patient data from a newly developed web-based system by the Japanese Society for Dialysis Therapy, the Web-based Analysis of Dialysis Data Archives system. Hb levels gradually increased from 2008 to 2019. Serum ferritin levels and transferrin saturation tended to increase between 2012 and 2019. Although these changes were found in all dialyzed patients, these were more pronounced in patients on peritoneal dialysis. We believe that our results can contribute to a better understanding of the results of clinical studies assessing the effects of treatment for anemia on clinical outcomes among dialyzed patients.
贫血治疗对于透析患者的管理至关重要。尽管 Hb 和血清铁蛋白水平通常被用作治疗的指标,但由于政策变化、贫血治疗药物以及临床指南建议的目标水平的变化,这些值会随时间而改变。为了阐明日本与贫血相关参数的长期变化,我们从日本透析治疗学会新开发的基于网络的分析透析数据档案系统中提取了年度患者数据。Hb 水平从 2008 年到 2019 年逐渐升高。血清铁蛋白水平和转铁蛋白饱和度在 2012 年至 2019 年间呈上升趋势。虽然这些变化在所有透析患者中都有发现,但在腹膜透析患者中更为明显。我们认为,我们的结果有助于更好地理解评估贫血治疗对透析患者临床结局影响的临床研究结果。