Department of Dermatology, University of Health Sciences, Sultan 2. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
Department of Pathology, University of Health Sciences, Sultan 2. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
J Cosmet Dermatol. 2022 Apr;21(4):1749-1752. doi: 10.1111/jocd.14321. Epub 2021 Jul 16.
Pagetoid dyskeratosis (PD), which is found in more than 2% of skin biopsy specimens, is accepted as a histopathological finding reflecting the abnormal keratinization process. However, to date, only a limited number of cases have been described to have brown pigmentation on the hands, triggered by friction, and present with pagetoid dyskeratosis as the only sign on histopathology and a parallel ridge pattern on dermoscopy.
To present and discuss the typical clinical, histopathological, and dermoscopic features of pagetoid dyskeratosis, and to draw attention to the spontaneous resolution following biopsy.
We present a case of pagetoid dyskeratosis with a palmar localization, which rapidly resolved following biopsy, in a patient with no history of friction.
PD is the only important histopathological finding in typical irregular pigmented lesions located in the hand. PD should also be considered in the differential diagnosis of lesions that show parallel ridge pattern on the hand. Two weeks after the biopsy, disappearance of the lesion may be due to the effect of inflammatory response revealed by biopsy.
Although the cause of this condition is not yet fully understood, most cases being associated with friction or rapid spontaneous resolution following biopsy, as in the current case, may indicate the reactive nature of the lesion. Further researches are required to be clarify etiology of PD.
Paget 样角化不良（PD）在超过 2%的皮肤活检标本中被发现，被认为是反映异常角化过程的组织病理学发现。然而，迄今为止，仅有少数病例在手受到摩擦刺激时出现棕色素沉着，并在组织病理学上表现为 PD 样角化不良，在皮肤镜下表现为平行脊状模式。
介绍和讨论 Paget 样角化不良的典型临床、组织病理学和皮肤镜特征，并提请注意活检后自发消退。
我们报告了一例手掌定位的 Paget 样角化不良病例，在无摩擦史的患者中，活检后迅速消退。
PD 是位于手部的典型不规则色素性病变中唯一重要的组织病理学发现。PD 也应考虑在手显示平行脊状模式的病变的鉴别诊断中。活检后两周，病变的消失可能是由于活检显示的炎症反应的影响。
尽管这种情况的原因尚不完全清楚，但大多数病例与摩擦有关，或如本例一样在活检后迅速自发消退，可能表明病变具有反应性。需要进一步研究以阐明 PD 的病因。
