Hacettepe University, Faculty of Medicine, Department of Pediatric Neurology, 06230, Ankara, Turkey.
Hacettepe University, Faculty of Medicine, Department of Pediatric Neurology, 06230, Ankara, Turkey.
Eur J Paediatr Neurol. 2021 Jul;33:125-134. doi: 10.1016/j.ejpn.2021.06.002. Epub 2021 Jun 17.
Childhood is a period where most vaccines are administered in order to build-up immunological memory, and immunization against vaccine-preventable diseases is an essential part of child care and health. The administration of vaccines to children with inflammatory diseases is a frequent point of concern for parents and physicians. Published information on the relation between vaccines and autoinflammatory diseases of the central nervous system (CNS) consists of case and cohort studies and reviews, in great majority on adult patients. Vaccines do not have any established causative or triggering effects on these diseases. Another issue is the immunization schedule of patients with autoinflammatory CNS diseases, specifically the interactions between the disorder, the clinical status, the treatment and the vaccine. In this review, we summarize the existing information between autoinflammatory disorders of the CNS and vaccines in childhood and underline the points to be considered under various treatment regimens.
儿童时期是接种大多数疫苗以建立免疫记忆的时期，预防疫苗可预防疾病的免疫接种是儿童保健和健康的重要组成部分。患有炎症性疾病的儿童接种疫苗是父母和医生经常关注的问题。关于疫苗与中枢神经系统（CNS）自身炎症性疾病之间关系的已发表信息包括病例和队列研究以及综述，其中大多数涉及成年患者。疫苗对这些疾病没有任何既定的因果或触发作用。另一个问题是患有自身炎症性中枢神经系统疾病的患者的免疫接种计划，特别是疾病、临床状况、治疗和疫苗之间的相互作用。在这篇综述中，我们总结了中枢神经系统自身炎症性疾病与儿童期疫苗之间的现有信息，并强调了在各种治疗方案下需要考虑的要点。
