Department of Mechanical Engineering, Isfahan University of Technology, Isfahan, 8415683111, Iran.
School of Mechanical Engineering, Pusan National University, Busan, 46241, Republic of Korea.
Comput Biol Med. 2021 Aug;135:104600. doi: 10.1016/j.compbiomed.2021.104600. Epub 2021 Jun 23.
In a new therapeutic technique, called magnetic drug targeting (MDT), magnetic particles carrying therapeutic agents are directed to the target tissue by applying an external magnetic field. Meanwhile, this magnetic field also affects the blood as a biomagnetic fluid. Therefore, it is necessary to select a magnetic field with an acceptable range of influence on the blood flow. This study investigates the effect of an external magnetic field on the pulsatile blood flow in a stenosed curved artery to identify a safe magnetic field. The effects of a number of parameters, including the magnetic susceptibility of blood in oxygenated and deoxygenated states and the magnetic field strength, were studied. Moreover, the effect of the plaque morphology, including the occlusion percentage and the chord length of the stenosis, on changes in blood flow induced by the magnetic field was investigated. The results show that applying a magnetic field increases the wall shear stress (WSS) and the pressure of the deoxygenated blood. Comparing the wall shear stresses of the deoxygenated and oxygenated blood shows that the effect of magnetic field on the deoxygenated blood is more significant than its effect on the oxygenated blood due to its higher magnetic susceptibility. The study of the stenosis geometry shows that the influence of magnetic field on the blood flow is increased by decreasing the occlusion percentage of the artery. Furthermore, among the evaluated lengths, the 50° chord length results in the highest variation under the influence of the magnetic field. Finally, the magnetic field of Mn = 2.5 can be utilized as a safe field for MDT purposes in such a stenosed curved artery.
在一种名为磁药物靶向（MDT）的新治疗技术中，通过施加外部磁场将携带治疗剂的磁性颗粒引导至目标组织。同时，该磁场还会影响作为生物磁流体的血液。因此，有必要选择一个对血流影响范围可接受的磁场。本研究旨在调查外部磁场对狭窄弯曲动脉中脉动血流的影响，以确定安全的磁场。研究了许多参数的影响，包括含氧和脱氧状态下血液的磁化率以及磁场强度。此外，还研究了斑块形态（包括狭窄处的闭塞百分比和狭窄长度）对磁场引起的血流变化的影响。结果表明，施加磁场会增加壁面切应力（WSS）和脱氧血液的压力。比较脱氧和含氧血液的壁面切应力表明，由于脱氧血液的磁化率更高，磁场对脱氧血液的影响比对含氧血液的影响更为显著。对狭窄几何形状的研究表明，通过降低动脉的闭塞百分比，磁场对血流的影响会增加。此外，在所评估的长度中，50°弦长在磁场的影响下会产生最高的变化。最后，可以将 Mn=2.5 的磁场用于此类狭窄弯曲动脉中的 MDT 目的作为安全磁场。
