大肠杆菌佐剂诱导大鼠间质性肾炎：免疫学研究结果
Interstitial nephritis in rats produced by E. coli in adjuvant: immunological findings.
作者信息
Sherlock J E
出版信息
Clin Exp Immunol. 1977 Oct;30(1):154-9.
Abstract
An increased incidence and severity of interstitial nephritis was produced in F344/fmai rats immunized with E. coli 022 in pertussis vaccine for 12-15 months. Migration of peritoneal exudate cells from immunized animals was inhibited by syngeneic kidney antigens. One out of twenty-eight immunized animals developed anti-TBM antibodies. In this model, interstitial nephritis develops in association with cell-mediated immunity to kidney tissue.
摘要
用百日咳疫苗中的大肠杆菌022免疫F344/fmai大鼠12至15个月后，间质性肾炎的发病率和严重程度增加。来自免疫动物的腹腔渗出细胞的迁移受到同基因肾抗原的抑制。28只免疫动物中有1只产生了抗肾小管基底膜抗体。在这个模型中，间质性肾炎与针对肾组织的细胞介导免疫相关。
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