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[如何应对可能改变细胞治疗正常活动的意外事件?法语国家骨髓移植与细胞治疗协会(SFGM-TC)的建议]

[How to deal with an unexpected event that could alter the normal activity of cellular therapy? Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

作者信息

Bay Jacques Olivier, Beguin Yves, Carpentier Alexandre, Dard Céline, Guillaume Thierry, Labussiere-Wallet Hélène, Lacassagne Marie Noëlle, Sauze Séverine, Yakoub-Agha Ibrahim, Chalandon Yves

机构信息

CHU Clermont-Ferrand, Service de thérapie cellulaire et d'hématologie clinique adulte, 1 place Lucie Aubrac, 63000 Clermont-Ferrand, France.

CHU de Liège et Université de Liège, Service d'Hématologie, Liège, Belgique.

出版信息

Bull Cancer. 2021 Dec;108(12S):S20-S25. doi: 10.1016/j.bulcan.2021.05.002. Epub 2021 Jun 30.

Abstract

The SARS-CoV-2 (COVID-19) pandemic has rapidly impacted cell therapy activities across the globe. Not only was this, unexpected event, a threat to patients who had previously received hematopoietic cell transplantation or other cell therapy such as CAR-T cells, but also, it was responsible for a disruption of cell therapy activities due to the danger of the virus and to the lack of solid scientific data on the management of patients and donors. The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) devoted a workshop to issue useful recommendations in such an unexpected event in order to harmonize the actions of all the actors involved in cellular therapy programs so that we can collectively face, in the future, the challenges that could threaten our patients. This work is not specifically dedicated to the SARS-CoV-2 outbreak, but the latter has been used as a concrete example of an unexpected event to build up our recommendations.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2,即新冠病毒)大流行迅速影响了全球的细胞治疗活动。这一突发事件不仅对先前接受过造血细胞移植或其他细胞治疗(如嵌合抗原受体T细胞疗法)的患者构成威胁,还因病毒的危险性以及缺乏关于患者和供体管理的可靠科学数据,导致细胞治疗活动中断。法语国家骨髓移植和细胞治疗协会(SFGM-TC)专门举办了一次研讨会,以便在这种突发事件中发布有用的建议,从而协调细胞治疗项目中所有相关方的行动,使我们能够在未来共同应对可能威胁患者的挑战。这项工作并非专门针对SARS-CoV-2疫情爆发,但后者已被用作突发事件的具体例子来制定我们的建议。

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