Unit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Medical Faculty of Heidelberg, University of Heidelberg, Heidelberg, Germany.
Br J Cancer. 2021 Sep;125(6):877-883. doi: 10.1038/s41416-021-01473-z. Epub 2021 Jul 2.
Cancer studies reported mixed results on benefit finding (BF) and posttraumatic growth (PTG) prevalence and few were focused on long-term survivors.
BF and PTG were assessed in a multi-regional population-based study in Germany with 6952 breast, colorectal and prostate cancer survivors, using the Benefit Finding Scale and Posttraumatic Growth Inventory. We calculated the age-adjusted prevalence, stratified by demographical and clinical characteristics.
Overall, 66.0% of cancer survivors indicated moderate-to-high BF, and 20.5% moderate-to-high PTG. Age-adjusted prevalence of BF and PTG differed according to cancer type (breast > colorectal > prostate) and sex (female > male). BF and PTG prevalence were higher in younger than in older respondents; the age-adjusted prevalence was higher in respondents who survived more years after diagnosis. The strength and direction of associations of age-adjusted prevalence with cancer stage, disease recurrence, and time since diagnosis varied according to cancer type and sex.
A substantial proportion of long-term cancer survivors reported moderate-to-high BF and PTG. However, the prevalence was lower in older and male cancer survivors, and during the earlier years after cancer diagnosis. Further longitudinal studies on PTG and BF in cancer survivors are warranted to address heterogeneity in survivors' experience after cancer diagnosis.
癌症研究报告了获益发现(BF)和创伤后成长(PTG)的发生率存在差异,且很少有研究关注长期幸存者。
本研究在德国开展了一项多区域基于人群的研究,纳入了 6952 例乳腺癌、结直肠癌和前列腺癌幸存者,采用获益发现量表和创伤后成长量表评估 BF 和 PTG。我们根据人口统计学和临床特征对其进行了分层,并计算了年龄调整后的发生率。
总体而言,66.0%的癌症幸存者报告了中高度 BF,20.5%的癌症幸存者报告了中高度 PTG。BF 和 PTG 的发生率因癌症类型(乳腺癌>结直肠癌>前列腺癌)和性别(女性>男性)而异。与年龄较大的受访者相比,年龄较小的受访者的 BF 和 PTG 发生率更高;诊断后生存时间较长的受访者的年龄调整后发生率更高。年龄调整后的发生率与癌症分期、疾病复发和诊断后时间的关联强度和方向因癌症类型和性别而异。
相当一部分长期癌症幸存者报告了中高度 BF 和 PTG。然而,年龄较大和男性癌症幸存者以及癌症诊断后早期的发生率较低。需要进一步开展关于癌症幸存者中 PTG 和 BF 的纵向研究,以解决癌症诊断后幸存者经历的异质性问题。