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Type 2 biomarker expression (FeNO and blood eosinophils) is higher in severe adult-onset than in severe early-onset asthma.

作者信息

Lommatzsch Marek, Klein Maria, Stoll Paul, Virchow Johann Christian

机构信息

Department of Pneumology and Critical Care Medicine, University of Rostock, Rostock, Germany.

出版信息

Allergy. 2021 Oct;76(10):3199-3202. doi: 10.1111/all.14997. Epub 2021 Jul 12.

DOI:10.1111/all.14997
PMID:34216489
Abstract
摘要

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Type 2 biomarker expression (FeNO and blood eosinophils) is higher in severe adult-onset than in severe early-onset asthma.在重度成人起病哮喘中,2型生物标志物表达(呼出气一氧化氮和血液嗜酸性粒细胞)高于重度早发型哮喘。
Allergy. 2021 Oct;76(10):3199-3202. doi: 10.1111/all.14997. Epub 2021 Jul 12.
2
Simultaneously elevated FeNO and blood eosinophils relate to asthma morbidity in asthmatics from NHANES 2007-12.同时升高的 FeNO 和血嗜酸性粒细胞与 NHANES 2007-12 中哮喘患者的哮喘发病率相关。
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Implication of fraction of exhaled nitric oxide and blood eosinophil count in severe asthma.呼出气一氧化氮分数与血嗜酸性粒细胞计数在重症哮喘中的意义。
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Both exhaled nitric oxide and blood eosinophil count were associated with mild allergic asthma only in non-smokers.呼出一氧化氮和血液嗜酸性粒细胞计数仅在不吸烟者中与轻度过敏性哮喘相关。
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Clinical and inflammatory features of asthma with dissociation between fractional exhaled nitric oxide and eosinophils in induced sputum.诱导痰中呼出气一氧化氮分数与嗜酸性粒细胞分离的哮喘的临床和炎症特征
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Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial.血嗜酸性粒细胞和呼出气一氧化氮对轻度哮喘成人的预测价值:一项开放标签、平行组、随机对照试验的预先指定亚组分析。
Lancet Respir Med. 2020 Jul;8(7):671-680. doi: 10.1016/S2213-2600(20)30053-9. Epub 2020 Mar 11.
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Combined value of exhaled nitric oxide and blood eosinophils in chronic airway disease: the Copenhagen General Population Study.呼出气一氧化氮与血嗜酸性粒细胞联合评估在慢性气道疾病中的价值:哥本哈根普通人群研究。
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Sputum interleukin-13 as a biomarker for the evaluation of asthma control.痰液白细胞介素-13作为评估哮喘控制的生物标志物。
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Relevance of TH2 Markers in the Assessment and Therapeutic Management of Severe Allergic Asthma: A Real-Life Perspective.TH2 标志物在严重过敏性哮喘评估和治疗管理中的相关性:现实视角。
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Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects.呼气一氧化氮水平和血嗜酸性粒细胞计数与美国国家健康和营养调查对象的喘息和哮喘事件独立相关。
J Allergy Clin Immunol. 2013 Oct;132(4):821-7.e1-5. doi: 10.1016/j.jaci.2013.06.007. Epub 2013 Jul 26.

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