Department of Neurology, First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Road, Harbin, 150001, Heilongjiang, China.
Cell Mol Biol Lett. 2021 Jul 3;26(1):31. doi: 10.1186/s11658-021-00274-9.
Developmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local tissue signal, it plays a regulatory role in the cancer microenvironment and inflammation. Del-1 has destructive effects in most cancers and is associated with the progression and invasion of some cancers. In contrast, Del-1 also plays a protective role in inflammation. Del-1 regulates inflammation by regulating the generation of neutrophils in bone marrow, inhibiting the recruitment and migration of neutrophils and accelerating the clearance of neutrophils by macrophages. Del-1 and IL-17 are reciprocally regulated, and their balance maintains immune system homeostasis. Del-1 is expected to become a new therapeutic target for inflammatory disorders such as multiple sclerosis.
发育内皮细胞定位因子-1（Del-1）是一种分泌型多功能结构域蛋白。它可以与整合素和磷脂酰丝氨酸结合。作为局部组织信号，它在肿瘤微环境和炎症中发挥调节作用。Del-1 在大多数癌症中具有破坏性作用，并与一些癌症的进展和侵袭有关。相比之下，Del-1 在炎症中也发挥保护作用。Del-1 通过调节骨髓中中性粒细胞的生成来调节炎症，抑制中性粒细胞的募集和迁移，并加速巨噬细胞清除中性粒细胞。Del-1 和 IL-17 是相互调节的，它们的平衡维持着免疫系统的稳态。Del-1 有望成为多发性硬化症等炎症性疾病的新治疗靶点。
