Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Santa Rosa, 39-57, 08950 Esplugues de Llobregat, Barcelona, Spain; Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu of Barcelona, Passeig Sant Joan de Déu, 002, 08950 Esplugues de Llobregat, Barcelona, Spain.
Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Santa Rosa, 39-57, 08950 Esplugues de Llobregat, Barcelona, Spain; Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu of Barcelona, Passeig Sant Joan de Déu, 002, 08950 Esplugues de Llobregat, Barcelona, Spain.
Psychiatry Res. 2021 Sep;303:114017. doi: 10.1016/j.psychres.2021.114017. Epub 2021 May 19.
Although psychosocial stress is consistently described as a casual factor for psychosis, the role of recent stressful life events (SLEs) is inconclusive. Studies with subjects with psychosis risk syndrome (PRS), fail to show a large number of SLEs but suggest greater stress sensitivity in these populations. We evaluate the presence of recent SLEs and stress sensitivity, and their relationship with symptoms and functionality in a sample consisting exclusively of help-seeking children and adolescents. Seventy-two 10- to 17-year-old help-seeking subjects who met PRS criteria and forty-two healthy control (HC) subjects participated in a naturalistic multi-site study. Measures of stress included the Stressful Life Events Schedule (SLES) and the G4 item of the Scale for Prodromal Syndromes (SOPS) scale. Child and adolescent PRS subjects presented greater number of SLEs during the previous year, greater total accumulated stress, greater sensitivity to stress, and more impaired tolerance to normal stress than did HC subjects. Stress measures showed a relationship with positive and negative attenuated symptoms, clinical variables and functionality. Our results support the role of stress in the PRS status. It reinforces the suggested differences for clinical presentation of PRS in terms of age, highlighting the importance of gathering data on the under-18 population.
虽然心理社会压力一直被描述为精神病的一个偶然因素，但最近的生活应激事件（SLEs）的作用尚无定论。对具有精神病风险综合征（PRS）的受试者的研究未能显示大量的 SLEs，但表明这些人群的应激敏感性更高。我们评估了最近 SLEs 和应激敏感性的存在及其与症状和功能的关系，该样本仅由寻求帮助的儿童和青少年组成。72 名 10 至 17 岁的寻求帮助的受试者符合 PRS 标准，42 名健康对照组（HC）受试者参加了一项自然主义多地点研究。应激措施包括应激生活事件量表（SLES）和前驱症状量表（SOPS）的 G4 项。与 HC 受试者相比，儿童和青少年 PRS 受试者在前一年经历了更多的 SLEs，累积的总应激更大，对压力的敏感性更高，对正常压力的耐受能力更差。应激测量结果与阳性和阴性症状减轻、临床变量和功能有关。我们的研究结果支持应激在 PRS 状态中的作用。它强化了 PRS 在年龄方面表现出的临床差异，强调了收集 18 岁以下人群数据的重要性。
