Division of Rheumatology, Department of Internal Medicine, Istanbul University -Cerrahpasa, Istanbul, Turkey.
Professor of Medicine, Division of Rheumatology, Department of Internal Medicine and Behçet's Disease Research Center, Istanbul University - Cerrahpasa, Istanbul, Turkey.
Expert Opin Pharmacother. 2021 Aug;22(12):1533-1537. doi: 10.1080/14656566.2021.1939307. Epub 2021 Jul 5.
Behçet's syndrome is a chronic, multi-system, variable vasculitis of unknown etiology that can result in significant morbidity and mortality. Mucocutaneous lesions such as oral ulcers and genital ulcers are common manifestations that can affect the quality of life of patients significantly. Treatment for mucocutaneous lesions in Behçet's syndrome continues to be critical, and an unmet need remains a significant issue.
This review evaluates the mechanism of action of apremilast, its effect on the number and pain of oral ulcers, other manifestations, such as genital ulcers, disease activity, quality of life and safety profile in Behçet's syndrome patients. Data from clinical trials as well as observational studies were included.
Two randomized placebo-controlled trials and real-world observational data suggest that apremilast is an effective and well-tolerated treatment modality for oral and genital ulcers in Behçet's syndrome. Observational studies additionally showed beneficial results for skin lesions, arthritis, and intestinal involvement.
贝赫切特综合征是一种病因不明的慢性、多系统、多变的血管炎，可导致严重的发病率和死亡率。口腔溃疡和生殖器溃疡等黏膜皮肤损害是常见的表现，可显著影响患者的生活质量。贝赫切特综合征黏膜皮肤损害的治疗仍然至关重要，未满足的需求仍然是一个重大问题。
本综述评估了阿普司特的作用机制，及其对口腔溃疡数量和疼痛、其他表现（如生殖器溃疡）、疾病活动度、生活质量和安全性的影响。纳入了临床试验和观察性研究的数据。
两项随机安慰剂对照试验和真实世界的观察性数据表明，阿普司特是治疗贝赫切特综合征口腔和生殖器溃疡的一种有效且耐受性良好的治疗方法。观察性研究还显示对皮肤损害、关节炎和肠病有有益的结果。
