靶向癌症中的丝氨酸：双管齐下是否更好？
Targeting Serine in Cancer: Is Two Better Than One?
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université de Paris, Paris, France.
出版信息
Trends Cancer. 2021 Aug;7(8):668-670. doi: 10.1016/j.trecan.2021.06.004. Epub 2021 Jul 1.
Abstract
Several recent preclinical studies have demonstrated that simultaneously blocking exogenous and endogenous sources of serine in malignant cells mediates superior anticancer effects as compared with limiting either source alone. Here, we critically summarize key developments in targeting serine to treat cancer and discuss persisting challenges for implementing such a therapeutic approach in patients.
摘要
最近的几项临床前研究表明，与单独限制任何一种来源相比，同时阻断恶性细胞中外源和内源性丝氨酸的来源可介导更优的抗癌作用。在这里，我们批判性地总结了靶向丝氨酸治疗癌症的关键进展，并讨论了在患者中实施这种治疗方法所面临的持续挑战。
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