Huang Dong, Cai Hui, Huang HaiYu
Oncology Hematology Department, Fengdu General Hospital, Fengdu County, Chongqing, 408200, China.
Discov Oncol. 2025 Apr 28;16(1):628. doi: 10.1007/s12672-025-02358-w.
Serine plays a vital role in various metabolic processes including the synthesis of proteins and other amino acids, which are essential for the cell proliferation and growth. Cancer cells either absorb exogenous serine or produce it through the serine synthesis pathway, enabling the generation of intracellular glycine and one-carbon units, which are crucial for nucleotide biosynthesis. This metabolic process, referred to as serine-glycine-one-carbon (SGOC) metabolism, is essential for tumorigenesis and exhibits considerable complexity and clinical significance. Enzymes involved in the SGOC pathway are linked to tumor growth, metastasis, and resistance to therapies. The SGOC pathway is a vital metabolic network that facilitates cell survival and proliferation, especially in aggressive cancers. Understanding how this network is regulated is crucial for tackling tumor heterogeneity and recurrence. This review emphasizes recent advancements in understanding the roles and effects of the SGOC metabolic pathway in the context of cancer progression. Additionally, it outlines the complex influences of the SGOC metabolic pathway on the tumor microenvironment (TME), offering potential strategies to enhance cancer immunotherapy.
丝氨酸在各种代谢过程中发挥着至关重要的作用，包括蛋白质和其他氨基酸的合成，而这些对于细胞增殖和生长至关重要。癌细胞要么吸收外源性丝氨酸，要么通过丝氨酸合成途径产生丝氨酸，从而能够生成细胞内甘氨酸和一碳单位，这对于核苷酸生物合成至关重要。这种代谢过程被称为丝氨酸-甘氨酸-一碳（SGOC）代谢，对肿瘤发生至关重要，并且表现出相当大的复杂性和临床意义。参与SGOC途径的酶与肿瘤生长、转移及对治疗的抗性相关联。SGOC途径是一个重要的代谢网络，有助于细胞存活和增殖，尤其是在侵袭性癌症中。了解该网络如何被调控对于应对肿瘤异质性和复发至关重要。本综述着重介绍了在理解SGOC代谢途径在癌症进展背景下的作用和影响方面的最新进展。此外，它概述了SGOC代谢途径对肿瘤微环境（TME）的复杂影响，提供了增强癌症免疫治疗的潜在策略。
