经二甲基亚砜或六亚甲基双乙酰胺诱导分化的弗氏红白血病细胞以及用诱导剂处理的非诱导性克隆的脂质特征。
Lipid characteristics of Friend erythroleukaemia cells differentiated by dimethyl sulphoxide or hexamethylenebisacetamide, and of non-inducible clones treated with the inducers.
作者信息
Fallani A, Arcangeli A, Ruggieri S
机构信息
Istituto di Patologia Generale dell'Università di Firenze, Italy.
出版信息
Biochem J. 1988 Jun 15;252(3):917-20. doi: 10.1042/bj2520917.
Abstract
We studied the lipid changes in Friend erythroleukaemia (FEL) cells differentiated by dimethyl sulphoxide (DMSO) or hexamethylenebisacetamide (HMBA). We also examined clones of FEL cells non-inducible to differentiation by DMSO or HMBA for lipid changes not related to the differentiation process. A decrease in triacylglycerols was found in both DMSO- or HMBA-differentiated FEL cells, whereas a decrease in phosphatidylethanolamine was observed only in DMSO-differentiated FEL cells. The characteristics of the phospholipid fatty acid profiles of FEL cells, which proved to be similar to those of other transformed cells, were not significantly affected by erythroid differentiation.
摘要
我们研究了经二甲基亚砜（DMSO）或六亚甲基双乙酰胺（HMBA）诱导分化的弗氏红白血病（FEL）细胞中的脂质变化。我们还检测了对DMSO或HMBA诱导分化无反应的FEL细胞克隆，以寻找与分化过程无关的脂质变化。在经DMSO或HMBA诱导分化的FEL细胞中均发现三酰甘油减少，而仅在经DMSO诱导分化的FEL细胞中观察到磷脂酰乙醇胺减少。FEL细胞的磷脂脂肪酸谱特征与其他转化细胞相似，红系分化对其没有显著影响。
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Changes in phospholipid and fatty acid composition in differentiated Friend leukaemic cells.分化的弗瑞德白血病细胞中磷脂和脂肪酸组成的变化
Biochem Biophys Res Commun. 1981 Jan 30;98(2):349-58. doi: 10.1016/0006-291x(81)90847-0.
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The effect of dimethylsulfoxide on the lipid composition of inducible and non inducible Friend leukemia cells.二甲基亚砜对诱导型和非诱导型弗瑞德白血病细胞脂质组成的影响。
Biochem Biophys Res Commun. 1982 Sep 30;108(2):437-46. doi: 10.1016/0006-291x(82)90848-8.
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