Chen Yu, Li Mingchao, Ji Qiuming, Su Zou, Yang Ziyu, Xu Yin, Chen Qian, Liao Dan, Zeng Jihua, Yang Yuhong
Department of Psychiatry, Wuhan Wudong Hospital, Wuhan, China.
Department of Psychiatry, Affiliated Wuhan Mental Health Center, Tong ji Medical College of Huazhong University Science and Technology, Wuhan, China.
Front Pharmacol. 2021 Jun 17;12:698740. doi: 10.3389/fphar.2021.698740. eCollection 2021.
To explore the clinical efficacy of paliperidone palmitate long-acting injection combined with electroacupuncture in the treatment of methamphetamine addicts. This study focused on methamphetamine addicts who were admitted to our hospital from January 2020 to December 2020 as the main research object, with a total of 89 cases. The patients were divided into a control group of 45 cases and a study group of 44 cases according to the treatment method. The control group was treated with electroacupuncture, and the study group was treated with paliperidone palmitate long-acting injection on the basis of electroacupuncture in the control group. After 6 months of continuous treatment, the treatment effect of methamphetamine withdrawal symptom score before and after treatment was used; Hamilton Anxiety Scale score and Hamilton Depression Scale were used to compare the anxiety and depression situation of the two groups; the brain wave α and θ wave situation of the two groups were compared. The results showed that there was no significant difference in the scores of Ma withdrawal symptoms, Hamilton Anxiety and Hamilton Depression between the two groups before treatment ( < 0.05); after 3 and 6 months of treatment, the scores of Ma withdrawal symptoms, Hamilton Anxiety and Hamilton Depression in the study group were significantly lower than those in the control group and the difference was statistically significant ( < 0.05); 6 months after the completion of the treatment, the α wave amplitude and Fourier transformed α brain wave (FFT) in the study group were significantly higher than those in the control group, and the difference was statistically significant ( < 0.05). Paliperidone palmitate long-acting injection combined with electroacupuncture is better than electroacupuncture alone in the treatment of methamphetamine addicts, and can significantly improve anxiety, depression and brain waves, thereby preventing addicts from relapse.
探讨棕榈酸帕利哌酮长效注射剂联合电针治疗甲基苯丙胺成瘾者的临床疗效。本研究以2020年1月至2020年12月我院收治的甲基苯丙胺成瘾者为主要研究对象，共89例。根据治疗方法将患者分为对照组45例和研究组44例。对照组采用电针治疗，研究组在对照组电针治疗的基础上加用棕榈酸帕利哌酮长效注射剂。连续治疗6个月后，采用甲基苯丙胺戒断症状治疗前后评分；采用汉密尔顿焦虑量表评分和汉密尔顿抑郁量表比较两组的焦虑和抑郁情况；比较两组的脑电波α波和θ波情况。结果显示，治疗前两组甲基苯丙胺戒断症状、汉密尔顿焦虑和汉密尔顿抑郁评分比较，差异无统计学意义（P>0.05）；治疗3个月和6个月后，研究组甲基苯丙胺戒断症状、汉密尔顿焦虑和汉密尔顿抑郁评分均显著低于对照组，差异有统计学意义（P<0.05）；治疗结束6个月后，研究组α波振幅和傅里叶变换α脑波（FFT）均显著高于对照组，差异有统计学意义（P<0.05）。棕榈酸帕利哌酮长效注射剂联合电针治疗甲基苯丙胺成瘾者的效果优于单纯电针治疗，能显著改善焦虑、抑郁及脑电波，从而预防成瘾者复吸。
