Kramer J H, Norman D, Brant-Zawadzki M, Ablin A, Moore I M
University of California, School of Medicine, San Francisco 94143.
Cancer. 1988 Mar 1;61(5):928-30. doi: 10.1002/1097-0142(19880301)61:5<928::aid-cncr2820610512>3.0.co;2-o.
Previous studies have shown that magnetic resonance imaging (MRI) is sensitive to white matter changes in children receiving cranial radiation of 3000 cGy or greater. The current study used MRI to investigate the integrity of white matter in children receiving 1800 to 2400 cGy of cranial radiation. Ten survivors of acute lymphoblastic leukemia (ALL) who received intrathecal methotrexate (MTX) and either 1800 or 2400 cGy of cranial radiation were studied with MRI and neuropsychologic testing. Magnetic resonance (MR) scans were normal in nine of ten patients. One patient had prominent and asymmetrical lateral ventricles and mildly enlarged cortical sulci. White matter tracts were normal in appearance. However, seven of nine children had below average intellectual functioning. Results indicate that children receiving less than 2500 cGy of cranial radiation fail to show white matter changes on MRI, despite evidence of cognitive impairment.
以往研究表明，磁共振成像（MRI）对接受3000厘戈瑞或更高剂量颅脑放疗的儿童白质变化敏感。本研究采用MRI来调查接受1800至2400厘戈瑞颅脑放疗儿童的白质完整性。对10名接受鞘内甲氨蝶呤（MTX）治疗且接受了1800或2400厘戈瑞颅脑放疗的急性淋巴细胞白血病（ALL）幸存者进行了MRI和神经心理学测试。10名患者中有9名的磁共振（MR）扫描结果正常。1名患者有明显且不对称的侧脑室以及轻度增宽的脑沟。白质束外观正常。然而，9名儿童中有7名智力功能低于平均水平。结果表明，接受低于2500厘戈瑞颅脑放疗的儿童尽管有认知障碍的证据，但在MRI上未显示白质变化。
