Zhao Chuan-Jie, Ma Guang-Zhen, Wang Yan-Jun, Wang Jin-Hong
Department of Hepatobiliary Surgery, Liaocheng Second People's Hospital, Linqing 252600, Shandong Province, China.
Department of Pathology, Liaocheng Second People's Hospital, Linqing 252600, Shandong Province, China.
World J Clin Cases. 2021 Jun 26;9(18):4765-4771. doi: 10.12998/wjcc.v9.i18.4765.
Kaposi's sarcoma (KS) is a malignancy that usually affects the skin of the lower extremities, and may involve internal organs. It originates from the vascular endothelium. It is well known that the development of KS is associated with human herpes virus 8 (. HHV8) infections. Sporadic KS cases have mainly been found in Africa. Isolated splenic KS in Asia has rarely been reported. We present here a case of KS primarily involving the spleen in a human immunodeficiency virus (HIV)-negative Chinese patient.
A 50-year-old male patient was admitted to hospital due to abdominal distension and discomfort, reduced food intake and weight loss. Medical examination revealed that the patient had moderate anemia, a low platelet count, slight fatty liver and a huge mass in the spleen. Spleen lymphoma was considered. An anti-HIV test was negative. The whole spleen was surgically excised. The final pathological diagnosis was nodular stage spleen KS, and the patient underwent total splenectomy. He recovered well and was discharged from hospital 12 d after surgery. Two weeks later, the patient developed liver metastasis and died within 1 mo after surgery.
KS is difficult to diagnose and pathological examination is necessary. KS has a poor prognosis and should be diagnosed and treated early to improve survival.
卡波西肉瘤（KS）是一种通常累及下肢皮肤且可能累及内脏器官的恶性肿瘤。它起源于血管内皮。众所周知，KS的发生与人类疱疹病毒8（HHV8）感染有关。散发性KS病例主要见于非洲。亚洲孤立性脾脏KS鲜有报道。我们在此报告一例主要累及脾脏的KS病例，该患者为人类免疫缺陷病毒（HIV）阴性的中国患者。
一名50岁男性患者因腹胀、不适、食欲减退和体重减轻入院。体格检查发现患者有中度贫血、血小板计数低、轻度脂肪肝和脾脏巨大肿块。考虑为脾淋巴瘤。抗HIV检测为阴性。手术切除了整个脾脏。最终病理诊断为结节期脾脏KS，患者接受了全脾切除术。术后恢复良好，术后12天出院。两周后，患者发生肝转移，术后1个月内死亡。
KS难以诊断，病理检查很有必要。KS预后较差，应早期诊断和治疗以提高生存率。
