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1例2019冠状病毒病患者发生极晚期双冠状动脉支架血栓形成的病例报告

Case report of a very late dual coronary stent thrombosis in a patient with coronavirus disease 2019.

作者信息

Hauguel-Moreau Marie, Lannou Simon, Bergez Léa, Mansencal Nicolas

机构信息

Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de référence des cardiomyopathies et des troubles du rythme cardiaque héréditaires ou rares, Université de Versailles-Saint Quentin (UVSQ), 9 avenue Charles de Gaulle, 92100 Boulogne, France.

INSERM U-1018, CESP, Épidémiologie clinique, Université de Versailles-Saint Quentin (UVSQ), 16 avenue Paul Vaillant Couturier, 94800 Villejuif, France.

出版信息

Eur Heart J Case Rep. 2021 Jun 7;5(6):ytab114. doi: 10.1093/ehjcr/ytab114. eCollection 2021 Jun.

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is associated with hypercoagulability and a high rate of thrombosis. Few cases of coronary stent thrombosis associated with COVID-19 have been reported.

CASE SUMMARY

In this report, we describe the case of a 65-year-old man with a history of coronary artery disease (CAD) who was admitted following an out-of-hospital cardiac arrest related to an ST-segment elevation myocardial infarction revealing a very late dual coronary stent thrombosis of the left anterior descending and posterior descending arteries. Ten days prior to admission, he was diagnosed with COVID-19 pneumonia and treated with dexamethasone, which led to rapid clinical improvement. After resuscitation, coronary angiography revealed an acute thrombotic occlusion in the two previous drug-eluting stents (implanted in 2010 and 2018), with a high thrombus burden. He was successfully treated by percutaneous coronary intervention. The patient did not present any further complications during his hospital stay and was transferred to a cardiac rehabilitation centre.

DISCUSSION

Dual stent thrombosis is an exceptional event highlighting the high procoagulant state promoted by coronavirus 19. This case suggests that strengthening of antithrombotic therapy in CAD patients presenting with COVID-19 should be discussed.

摘要

背景

2019冠状病毒病(COVID-19)与高凝状态及高血栓形成率相关。与COVID-19相关的冠状动脉支架血栓形成病例报道较少。

病例摘要

在本报告中,我们描述了一名65岁有冠状动脉疾病(CAD)病史的男性病例,该患者因与ST段抬高型心肌梗死相关的院外心脏骤停入院,结果显示左前降支和后降支出现极晚期双冠状动脉支架血栓形成。入院前10天,他被诊断为COVID-19肺炎,并接受地塞米松治疗,临床症状迅速改善。复苏后,冠状动脉造影显示两个先前植入的药物洗脱支架(分别于2010年和2018年植入)出现急性血栓闭塞,血栓负荷较高。他通过经皮冠状动脉介入治疗成功治愈。患者在住院期间未出现任何进一步并发症,并被转至心脏康复中心。

讨论

双支架血栓形成是一个罕见事件,突出了新型冠状病毒所引发的高促凝状态。该病例提示,对于患有COVID-19的CAD患者,应讨论加强抗栓治疗。

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