Chetty Sarentha, Reddy Millidhashni, Ramsamy Yogandree, Naidoo Anushka, Essack Sabiha
Discipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
Essential Medicine Consulting, Durban, South Africa.
JAC Antimicrob Resist. 2019 Nov 28;1(3):dlz060. doi: 10.1093/jacamr/dlz060. eCollection 2019 Dec.
To map published data of antimicrobial stewardship (AMS) interventions that are currently being carried out in hospitals and clinics in the public and private health sectors of South Africa in line with the antimicrobial resistance (AMR) strategy of South Africa.
A systematic scoping review was conducted to identify AMS initiatives in the public and private health sectors of South Africa for the period 1 January 2000 to 31 March 2019. An electronic search of databases was made including PubMed, Scopus, a key medical journal (), University of KwaZulu-Natal (UKZN) WorldCat iCatalogue and AMR networks: Federation of Infectious Diseases Societies in South Africa (FIDSSA). Reference lists of published articles were also reviewed for inclusion. Keywords included 'antimicrobial antibiotic stewardship South Africa'.
Of a total of 411 articles, using a stepwise screening process, 18 articles were selected for inclusion in the review. The interventions/initiatives were divided into four broad categories: (i) AMS intervention: prescription audits and usage; (ii) AMS intervention: education and its impact; (iii) other AMS interventions; and (iv) the role of different healthcare professionals in AMS.
The data identifies a need for and the value of AMS in both the public and private health sectors of South Africa. Initiatives are carried out across both sectors but more attention needs to be focused on AMS implementation in line with the National AMR Strategy of South Africa. Collaboration between the different sectors will aid in overcoming the AMR challenge.
梳理与南非抗菌药物耐药性（AMR）战略相符的、目前在南非公共和私营卫生部门的医院及诊所开展的抗菌药物管理（AMS）干预措施的已发表数据。
开展了一项系统性的范围综述，以确定2000年1月1日至2019年3月31日期间南非公共和私营卫生部门的AMS举措。对数据库进行了电子检索，包括PubMed、Scopus、一份关键医学期刊（）、夸祖鲁 - 纳塔尔大学（UKZN）世界Cat iCatalogue以及AMR网络：南非传染病协会联合会（FIDSSA）。还对已发表文章的参考文献列表进行了审查以确定是否纳入。关键词包括“南非抗菌抗生素管理”。
在总共411篇文章中，通过逐步筛选过程，选择了18篇文章纳入综述。这些干预措施/举措分为四大类：（i）AMS干预：处方审核与使用；（ii）AMS干预：教育及其影响；（iii）其他AMS干预；以及（iv）不同医疗保健专业人员在AMS中的作用。
数据表明南非公共和私营卫生部门对抗菌药物管理既有需求也有其价值。两个部门都开展了相关举措，但需要更加关注按照南非国家抗菌药物耐药性战略实施抗菌药物管理。不同部门之间的合作将有助于应对抗菌药物耐药性挑战。
