自递送纳米医学用于化疗增敏光动力疗法。
Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy.
机构信息
School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, P. R. China.
出版信息
Chem Commun (Camb). 2021 Jul 28;57(59):7296-7299. doi: 10.1039/d1cc02318g. Epub 2021 Jul 5.
A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system for enhanced PDT, which provides synergistic effects for tumor precision therapy in consideration of the unfavorable tumor microenvironments.
一种基于氯 e6（Ce6）和姜黄素（Cur）的自递送纳米药物（CeCu）被制备用于化疗增敏光动力疗法（PDT）。Cur 的化疗药物可以抑制 TrxR 活性，破坏细胞内的 ROS 防御系统，以增强 PDT，考虑到不利的肿瘤微环境，这为肿瘤精准治疗提供了协同作用。
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