Department of Basic Medicine, Xi'an Medical University, Xin-Wang Street #1, Xi'an, 710021, Shaanxi, China.
Cell Mol Neurobiol. 2022 Nov;42(8):2439-2448. doi: 10.1007/s10571-021-01124-0. Epub 2021 Jul 5.
Nogo proteins, also known as Reticulon-4, have been identified as myelin-derived inhibitors of neurite outgrowth in the central nervous system (CNS). There are three Nogo variants, Nogo-A, Nogo-B and Nogo-C. Recent studies have shown that Nogo-A/B is abundant in macrophages and may have a wider effect on inflammation. In this review, we focus mainly on the possible roles of Nogo-A/B on polarization and recruitment of macrophages and their involvement in a variety of inflammatory diseases. We then discuss the Nogo receptor1 (NgR1), a common receptor for Nogo proteins that is also abundant in microglia/macrophage in the CNS. Interaction of Nogo and NgR1 in microglia/macrophage may affect the adhesion and polarization of macrophages that are involved in multiple neurodegenerative diseases, including Alzheimer's disease and multiple sclerosis. Overall, this review provides insights into the roles of Nogo proteins in regulating macrophage functions and suggests that, potentially, Nogo proteins maybe a new target in the treatment of inflammatory diseases.
神经生长锥抑制蛋白（Nogo），又称为 Reticulon-4，已被鉴定为中枢神经系统（CNS）中髓鞘来源的神经突生长抑制剂。Nogo 有三种变体，分别为 Nogo-A、Nogo-B 和 Nogo-C。最近的研究表明，Nogo-A/B 在巨噬细胞中含量丰富，可能对炎症有更广泛的影响。在这篇综述中，我们主要关注 Nogo-A/B 对巨噬细胞极化和募集的可能作用及其在各种炎症性疾病中的参与。然后，我们讨论了 Nogo 受体 1（NgR1），它是 Nogo 蛋白的共同受体，在中枢神经系统的小胶质细胞/巨噬细胞中也大量存在。Nogo 与 NgR1 在小胶质细胞/巨噬细胞中的相互作用可能影响参与多种神经退行性疾病（包括阿尔茨海默病和多发性硬化症）的巨噬细胞的黏附和极化。总的来说，这篇综述提供了对 Nogo 蛋白在调节巨噬细胞功能中的作用的深入了解，并表明 Nogo 蛋白可能是治疗炎症性疾病的新靶点。
