Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Santa Maria, Brazil.
Graduate Program in Nanoscience, Franciscan University, Santa Maria, Brazil, Santa Maria, Brazil.
Biofouling. 2021 May;37(5):555-571. doi: 10.1080/08927014.2021.1939019. Epub 2021 Jul 5.
Microbial infections caused by sessile microorganisms are known to be a more challenging issue than infections caused by the same microorganisms in the planktonic state. is an opportunistic pathogen and biofilm-forming agent. This species presents intense cellular communication mediated by signaling molecules. This process is known as quorum sensing (QS) and induces the transcription of specific genes that favors cell density growth and three-dimensional bacterial grouping. In this context, the discovery of compounds capable of inhibiting the action of the QS signaling molecules seems to be a promising strategy against biofilms. This work aimed to evaluate the anti-biofilm action and the safety profile of a sulfamethoxazole-Ag complex. The results obtained indicate potential anti-biofilm activity through QS inhibition. tests showed that the compound acts on the las and pqs systems, which are the main regulators of biofilm formation in . Additionally, the molecule proved to be safe for human peripheral blood mononuclear cells.
众所周知，与浮游状态的同种微生物引起的感染相比，由固着微生物引起的微生物感染是一个更具挑战性的问题。 是一种机会性病原体和生物膜形成剂。该物种通过信号分子进行强烈的细胞间通讯。这个过程被称为群体感应（QS），并诱导有利于细胞密度生长和三维细菌聚集的特定基因的转录。在这种情况下，发现能够抑制 QS 信号分子作用的化合物似乎是对抗生物膜的一种有前途的策略。这项工作旨在评估磺胺甲恶唑-银复合物的抗生物膜作用和 安全性。获得的结果表明，该化合物通过抑制 QS 具有潜在的抗生物膜活性。 测试表明，该化合物作用于 las 和 pqs 系统，这是 生物膜形成的主要调节剂。此外，该分子被证明对人外周血单核细胞是安全的。
