Research Center of Neurology, Moscow, 125367, Russia.
Biochemistry (Mosc). 2021 Jun;86(6):737-745. doi: 10.1134/S0006297921060110.
The review summarizes the results of studies on the cellular and molecular mechanisms mediating the impact of stress on the pathogenesis of neurodegenerative brain pathologies (Alzheimer's disease, Parkinson's disease, etc.) and presents current information on the role of stress in the hyperphosphorylation of tau protein, aggregation of beta-amyloid, and hyperactivation of the hypothalamic-pituitary-adrenal axis involved in the hyperproduction of factors that contribute to the pathogenetic role of stress in neurodegeneration. The data on the participation of microglia in the effects of stress on the pathogenesis of neurodegenerative diseases are presented.
该综述总结了研究应激对神经退行性脑病理（如阿尔茨海默病、帕金森病等）发病机制影响的细胞和分子机制的结果，并介绍了应激在涉及促进神经退行性病变中应激致病作用的因素过度产生的tau 蛋白过度磷酸化、β-淀粉样蛋白聚集和下丘脑-垂体-肾上腺轴过度激活中的作用的最新信息。还介绍了小胶质细胞参与应激对神经退行性疾病发病机制影响的数据。
