Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences, Hainan University, Haikou, Hainan 570228, China.
Curr Top Med Chem. 2021;21(13):1129-1138. doi: 10.2174/1568026621666210705164319.
Outer membrane protein A (OmpA) is a unique outer membrane protein which is abundantly present in the outer membrane of Gram-negative bacteria. OmpA is a transmembrane structural protein with a conserved amino acid sequence among different bacteria. This protein is involved in a number of functions like adhesion, toxicity, invasiveness, and biofilm formation in Gram-negative bacteria. Many studies have proposed that OmpA could be a therapeutic target for bacterial infection. Our review focusses on the studies involving recent development in the structure and functions of OmpA and further discussing its potential as a therapeutic target for bacterial infection.
外膜蛋白 A（OmpA）是一种存在于革兰氏阴性菌外膜中的独特外膜蛋白。OmpA 是一种跨膜结构蛋白，在不同细菌中有保守的氨基酸序列。这种蛋白参与了许多功能，如革兰氏阴性菌的粘附、毒性、侵袭和生物膜形成。许多研究表明，OmpA 可能是细菌感染的治疗靶点。我们的综述重点介绍了涉及 OmpA 结构和功能的最新研究进展，并进一步讨论了其作为细菌感染治疗靶点的潜力。
