Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1655/76, 32300 Pilsen, Czech Republic.
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1655/76, 32300 Pilsen, Czech Republic; Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 80, 32300 Pilsen, Czech Republic.
Mater Sci Eng C Mater Biol Appl. 2021 Aug;127:112203. doi: 10.1016/j.msec.2021.112203. Epub 2021 May 21.
Seriously compromised function of some organs can only be restored by transplantation. Due to the shortage of human donors, the need to find another source of organs is of primary importance. Decellularized scaffolds of non-human origin are being studied as highly potential biomaterials for tissue engineering. Their biological nature and thus the ability to provide a naturally-derived environment for human cells to adhere and grow highlights their great advantage in comparison to synthetic scaffolds. Nevertheless, since every biomaterial implanted in the body generates immune reaction, studying the interaction of the scaffold with the surrounding tissues is necessary. This review aims to summarize current knowledge on the immunogenicity of semi-xenografts involved in transplantation. Moreover, positive aspects of the interaction between xenogeneic scaffold and human cells are discussed, focusing on specific roles of proteins associated with extracellular matrix in cell adhesion and signalling.
一些器官的严重功能障碍只能通过移植来恢复。由于人类供体的短缺，寻找另一种器官来源至关重要。非人类来源的去细胞化支架作为组织工程的高潜力生物材料正在被研究。它们的生物性质，以及为人类细胞提供附着和生长的天然衍生环境的能力，使它们与合成支架相比具有巨大的优势。然而，由于植入体内的每一种生物材料都会引发免疫反应，因此有必要研究支架与周围组织的相互作用。本综述旨在总结目前关于移植中涉及的半异种移植物免疫原性的知识。此外，还讨论了异种支架与人类细胞相互作用的积极方面，重点讨论了与细胞粘附和信号转导相关的细胞外基质蛋白的特定作用。
