Barbata G, Carbone P, Giglio M C, Santoro A, Granata G
Dipartimento di Biologia Cellulare e dello Sviluppo A. Monroy, Sezione di Genetica, Università di Palermo, Italy.
Cancer Genet Cytogenet. 1988 Feb;30(2):333-6. doi: 10.1016/0165-4608(88)90204-x.
A rare cytogenetic finding in chronic myeloid leukemia is reported. It consisted in a "masked" Philadelphia chromosome, resulting from an unusual translocation between chromosomes #22 and X. The t(X;22) was present in 100% of direct and cultured bone marrow cell preparations. Chromosome #9 did not seem to be involved in the formation of the Ph marker. Involvement of the X chromosome in karyotypic changes of hematologic diseases, with particular respect to chronic myeloid leukemia, is discussed.
报告了1例慢性髓性白血病罕见的细胞遗传学发现。其表现为一条“隐匿”的费城染色体，由22号与X染色体之间异常易位所致。在直接制备及培养的骨髓细胞样本中，t(X;22)均为100%。9号染色体似乎未参与费城染色体标记的形成。本文讨论了X染色体在血液系统疾病核型改变中的作用，尤其是在慢性髓性白血病中的作用。
