Biswas Durba, Maiti Chikam, Talukder Biplabendu, Azharuddin Md, Saha Sayantan, Pandey Sumita, Das Arijit, Adhikari Setu Das, Ray Yogiraj, Sarkar Biswanath S, Paul Sekhar R, Saha Bibhuti, Paul Sandip, Chatterjee Shilpak, Ganguly Dipyaman, Bhattacharya Prasun
Department of Immunohematology and Blood Transfusion Medical College and Hospital Kolkata India.
Department of Medicine I.D&B.G Hospital Kolkata India.
ISBT Sci Ser. 2021 Nov;16(4):276-283. doi: 10.1111/voxs.12639. Epub 2021 Jun 1.
The COVID-19 pandemic has spread across 87 million people with more than 1·8 million deaths in the world. As there is no definite treatment modality, the use of convalescent plasma has become increasingly popular worldwide. This study aimed to identify an appropriate strategy of donor recruitment and to evaluate the appropriateness of pre-set plasma donation guidelines.
In this prospective study conducted from May to September 2020, the donors were recruited under the following two circumstances: Group I, patients in the post-COVID-19 follow-up in the clinic, and Group II, patients recovered from COVID-19 recruited through mass and electronic media. A pre-set donor selection criteria and laboratory investigation was designed according to national and international guidelines. Approximately 500 ml of COVID-19 convalescent plasma (CCP) was collected from recovered individuals in each group by two different cell separators. The overall donor's attendance rate, deferral rate, adverse events and donor compliance was analysed and compared between the two groups.
There was a significant difference in attendance in relation to registration between the groups ( < 0·0001). Donor deferral was significantly higher in group II compared with group I. The single most frequent cause of donor deferral was low antibody index ( = 0·0001). The total donor adverse event rate in CCP donation was significantly lower compared with routine plateletpheresis procedures. The donor's compliance to blood centre's protocol was satisfactory in both the groups.
Recruitment of patients in the post-COVID-19 follow-up in the clinic was more effective than the general recruitment through mass and electronic media for convalescence plasma donation in a resource-constrained blood centre.
新冠疫情已在全球蔓延，感染人数达8700万，死亡人数超过180万。由于尚无明确的治疗方式，康复期血浆的使用在全球范围内越来越普遍。本研究旨在确定合适的献血者招募策略，并评估预设血浆捐献指南的适用性。
在这项于2020年5月至9月进行的前瞻性研究中，在以下两种情况下招募献血者：第一组，门诊中新冠康复后的随访患者；第二组，通过大众和电子媒体招募的新冠康复患者。根据国家和国际指南设计了预设的献血者选择标准和实验室检查。通过两种不同的细胞分离器从每组康复个体中采集约500毫升新冠康复期血浆（CCP）。分析并比较两组之间的总体献血者出勤率、延期率、不良事件和献血者依从性。
两组在登记后的出勤率存在显著差异（<0.0001）。第二组的献血者延期率显著高于第一组。献血者延期的最常见单一原因是抗体指数低（=0.0001）。与常规血小板单采程序相比，CCP捐献中的总献血者不良事件率显著更低。两组献血者对血站方案的依从性均令人满意。
在资源有限的血站中，对于康复期血浆捐献，招募门诊中新冠康复后的随访患者比通过大众和电子媒体进行一般招募更有效。
