Grob P J, Joller-Jemelka H, Lüthy R, Täuber M, Ledergerber B, Brühwiler J, Fierz W
Departement für Innere Medizin, Universitätsspital, Zürich.
Schweiz Med Wochenschr. 1988 Jan 16;118(2):58-64.
53 individuals negative for anti-HIV by screening test and 79 individuals positive for anti-HIV were prospectively surveyed for clinical progression and by quantitatively measuring anti-p24 (antibodies against an HIV core protein), anti-gp41 (antibodies against an HIV surface protein) and HIV-(p24) antigen. The patients were classified into four categories of HIV-markers: 1. Anti-p24 in high concentrations, HIV-Ag negative, 2. anti-p24 in high concentrations, HIV-Ag positive (most often transitory only), 3. anti-p24 absent/deficient, HIV-Ag negative and 4. anti-p24 absent/deficient and HIV-AG positive. Within a minimum of 18 months, 4 of the 53 (8%) initially anti-HIV negative individuals contracted HIV infection. 17 of the 79 (22%) initially anti-HIV positive individuals showed disease progression. 8 of the patients in category 4 already had AIDS when entering the study, and 3 of the 6 (5%) remaining patients of this category developed AIDS. Amongst the 19 patients in the third category 2 individuals (11%) developed AIDS and in a further 5 (26%) individuals the disease progressed but in no case to AIDS. None of the patients of the categories 1 and 2 developed AIDS but 2 of the 10 (20%) individuals in the second category and 3 of the 29 (10%) in the first category showed disease progression but not to AIDS. In conclusion, the quantitative measurement of anti-p24 and of HIV-Ag affords prognostic pointers for the clinical outcome of HIV infection.
对53名筛查试验抗HIV阴性个体和79名抗HIV阳性个体进行前瞻性调查，观察临床进展情况，并定量检测抗p24（针对HIV核心蛋白的抗体）、抗gp41（针对HIV表面蛋白的抗体）和HIV - (p24)抗原。患者被分为四类HIV标志物：1. 高浓度抗p24，HIV抗原阴性；2. 高浓度抗p24，HIV抗原阳性（大多仅为短暂性）；3. 抗p24缺失/不足，HIV抗原阴性；4. 抗p24缺失/不足且HIV抗原阳性。在至少18个月内，53名最初抗HIV阴性个体中有4名（8%）感染了HIV。79名最初抗HIV阳性个体中有17名（22%）出现疾病进展。第4类中的8名患者在进入研究时已患有艾滋病，该类其余6名患者中有3名（5%）发展为艾滋病。在第3类的19名患者中，有2名（11%）发展为艾滋病，另有5名（26%）患者病情进展但未发展为艾滋病。第1类和第2类患者均无发展为艾滋病的情况，但第2类10名患者中有2名（20%）、第1类29名患者中有3名（10%）病情进展但未发展为艾滋病。总之，抗p24和HIV抗原的定量检测可为HIV感染的临床结局提供预后指标。
