Professor(Junior Gr.), Dept. of Medicine, Dr. RMLIMS, Lucknow, Uttar Pradesh.
Professor and Head, Dept. of Medicine, Era's Lucknow Medical College, Lucknow, Uttar Pradesh.
J Assoc Physicians India. 2021 Jan;69(1):32-35.
The increasing incidence of nephrolithiasis in recent decades is coinciding with rising epidemic of obesity, metabolic syndrome, and type 2 diabetes. This temporal concordance suggests that a link might exist between these metabolic abnormalities and urinary stone disease. Therefore, the present study was aimed to investigate the association between presence of risk factors of nephrolithiasis and metabolic syndrome.
In a hospital-based, case control study, hundred patients of metabolic syndrome diagnosed according to IDF criteria and hundred age and matched controls were studied for presence of risk factors of nephrolithiasis.
Patients with metabolic syndrome had significantly higher uricosuri a,hypercalciuria,oxaluria and hypocitraturia. The prevalence of risk factors of nephrolithiasis was also higher in patients with metabolic syndrome. The most prevalent was low urinary pH in 40% patients with mean pH of 5.8±1.6. Amongst other factors, 33% had hyperuricemia, 29% had hypercalciuria, 15% had oxaluria 13% had hypocitraturia and 10% had hyperuricosuria. Significant correlation was observed between risk factors of nephrolithiasis and components of metabolic syndrome.
The present study provides an evidence of association between risk factors of nephrolithiasis and metabolic syndrome and suggests that nephrolithiasis may be a systemic disorder representing the interaction of multiple metabolic derangements. Determining common modifiable risk factors for the development of kidney stones might uncover new preventive strategies.
近几十年来，肾结石的发病率不断上升，同时肥胖症、代谢综合征和 2 型糖尿病的流行也呈上升趋势。这种时间上的一致性表明，这些代谢异常与尿石症之间可能存在联系。因此，本研究旨在探讨肾结石危险因素与代谢综合征之间的关系。
在一项基于医院的病例对照研究中，我们研究了 100 例根据 IDF 标准诊断为代谢综合征的患者和 100 例年龄匹配的对照者中肾结石危险因素的存在情况。
代谢综合征患者的尿酸排泄增多、高钙尿症、高草酸尿症和低枸橼酸尿症更为明显。代谢综合征患者的肾结石危险因素患病率也较高。最常见的是 40%的患者尿液 pH 值较低，平均 pH 值为 5.8±1.6。其他因素中，33%的患者血尿酸升高，29%的患者高钙尿症，15%的患者高草酸尿症，13%的患者低枸橼酸尿症，10%的患者高尿酸尿症。肾结石危险因素与代谢综合征的各组分之间存在显著相关性。
本研究提供了肾结石危险因素与代谢综合征之间存在关联的证据，并表明肾结石可能是一种全身性疾病，代表多种代谢紊乱的相互作用。确定肾结石发生的共同可改变危险因素可能会发现新的预防策略。
