Nanda R, Asano T, Kenny J J, Topazian R G
Department of Orthodontics, School of Dental Medicine, Unviersity of Connecticut, Farmington.
Am J Orthod Dentofacial Orthop. 1988 Mar;93(3):224-31. doi: 10.1016/s0889-5406(88)80007-6.
The purpose of this study was to investigate the histologic appearance of temporomandibular joints of monkeys who had undergone total maxillary osteotomy. The specific aim of the study was to seek clues that might explain the inhibition in the mandibular growth 27 months following the surgery performed on adolescent monkeys. Eighteen female adolescent Macaca fascicularis monkeys were used. Eight served as control and ten were experimental. All experimental animals underwent 3.0 to 5.0 mm superior and 0.5 to 2.5 mm anterior repositioning of the maxilla. All animals were killed 27 months after the surgical procedure. Qualitative and quantitative histologic evaluations of the temporomandibular joints were done and results were compared with the cephalometric data. The findings showed no pathologic changes, although the histologic appearance of the temporomandibular joints of the experimental animals was more mature than that of the controls. The histologic results support cephalometric findings and the data are discussed in relationship to the role of maxilla, maxillary teeth, and occlusion in regulating mandibular growth.
本研究的目的是调查接受全上颌骨切开术的猴子颞下颌关节的组织学表现。该研究的具体目标是寻找线索，以解释在青春期猴子接受手术后27个月下颌生长受到抑制的原因。使用了18只雌性青春期食蟹猴。8只作为对照，10只为实验动物。所有实验动物的上颌均进行了3.0至5.0毫米的向上和0.5至2.5毫米的向前重新定位。所有动物在手术27个月后处死。对颞下颌关节进行了定性和定量的组织学评估，并将结果与头影测量数据进行了比较。研究结果显示无病理变化，尽管实验动物颞下颌关节的组织学表现比对照组更成熟。组织学结果支持头影测量结果，并结合上颌骨、上颌牙齿和咬合在调节下颌生长中的作用对数据进行了讨论。
