Department of Orthopaedics and Traumatology, 64048Uludag University Faculty of Medicine, Uludag University Faculty of Medicine, Bursa, Turkey.
Department of Anesthesiology and Intensive Care, Uludag University Faculty of Medicine, Bursa, Turkey.
J Int Med Res. 2021 Jul;49(7):3000605211024875. doi: 10.1177/03000605211024875.
To evaluate the effect of high-dose prednisolone on the functional outcome of patients with early-stage primary frozen shoulder.
Eighteen patients treated with oral prednisolone at an initial dose of 1 mg/kg/day for primary frozen shoulder were retrospectively evaluated. The patients' range of motion, Disabilities of the Arm, Shoulder, and Hand (DASH) score, Constant-Murley score, American Shoulder and Elbow Surgeons (ASES) score, and visual analog scale score were recorded at baseline and at 4 weeks and 6 months after treatment.
Rapid recovery of shoulder motion was noted at 4 weeks with the exception of abduction, which was maintained at 6 months. Significant improvement in pain perception and the Constant-Murley score was evident at 4 weeks and extended to 6 months. The DASH and ASES scores did not show significant improvement in the first 4 weeks but were significantly improved at 6 months.
High-dose oral prednisolone treatment provides rapid symptom resolution that persists long after drug discontinuation. The early treatment period is characterized by marked reduction in pain and rapid recovery of shoulder motion. Improvements in functional outcomes and disability indices tend to be more subtle in the early period but significantly improve during late treatment.
评估大剂量泼尼松龙对早期原发性冻结肩患者功能结局的影响。
回顾性评估了 18 例接受口服泼尼松龙治疗的原发性冻结肩患者，初始剂量为 1mg/kg/天。在基线时以及治疗后 4 周和 6 个月时，记录患者的关节活动度、手臂、肩部和手的残疾程度（DASH）评分、Constant-Murley 评分、美国肩肘外科医生协会（ASES）评分和视觉模拟评分。
在第 4 周时，除外展外，肩部运动得到了快速恢复，这种情况一直持续到第 6 个月。在第 4 周时，疼痛感知和 Constant-Murley 评分显著改善，并持续到第 6 个月。在最初的 4 周内，DASH 和 ASES 评分没有显著改善，但在第 6 个月时显著改善。
大剂量口服泼尼松龙治疗可迅速缓解症状，且停药后持续时间长。早期治疗阶段的特点是疼痛明显减轻，肩部运动迅速恢复。在早期，功能结局和残疾指数的改善较为微妙，但在晚期治疗时会显著改善。
