葡萄糖转运蛋白 1 在胰腺癌中的表达及生存意义：Meta 分析、生物信息学分析及回顾性研究。

The Expression and Survival Significance of Glucose Transporter-1 in Pancreatic Cancer: Meta-Analysis, Bioinformatics Analysis and Retrospective Study.

机构信息

Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, The People's Republic of China.

Department of Pathology, Huashan Hospital, Fudan University, Shanghai, The People's Republic of China.

出版信息

Cancer Invest. 2021 Oct;39(9):741-755. doi: 10.1080/07357907.2021.1950755. Epub 2021 Aug 3.

DOI:10.1080/07357907.2021.1950755

PMID:34229540

Abstract

To explore the expression profile and prognostic relevance of GLUT-1 in pancreatic cancer, a meta-analysis, bioinformatics analysis based on Gene Expression Omnibus (GEO), Oncomine dataset and The Cancer Genome Atlas (TCGA) database, and immunohistochemistry in tumor and normal tissue from 88 pancreatic ductal adenocarcinoma (PDAC) patients were performed. GLUT-1 was significantly overexpressed in pancreatic cancer but it could not be a significant biomarker for prognosis. TNM stage and pathological grade could be biomarker of poor prognosis of patients with pancreatic cancer.

摘要

为了探究 GLUT-1 在胰腺癌中的表达谱及其与预后的相关性，我们进行了一项荟萃分析、基于基因表达综合数据库（GEO）的生物信息学分析、Oncomine 数据集和癌症基因组图谱（TCGA）数据库的分析，并对 88 名胰腺导管腺癌（PDAC）患者的肿瘤和正常组织进行了免疫组织化学分析。GLUT-1 在胰腺癌中显著过表达，但不能作为预后的显著生物标志物。TNM 分期和病理分级是胰腺癌患者预后不良的生物标志物。