Department of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 North Street Clair, Suite 1900, Chicago, IL 60611, USA.
Clin Liver Dis. 2021 Aug;25(3):595-602. doi: 10.1016/j.cld.2021.03.005. Epub 2021 May 26.
Alcohol-associated hepatitis is associated with poor outcomes, especially when severe. Despite extensive study with a plethora of potential therapeutic agents, treatment options remain limited, with the current standard of therapy being corticosteroids. Granulocyte colony-stimulating factor is an alternate agent that seems promising, although further study in a more heterogenous patient population is needed before implementation. Adjuncts to therapy that are often overlooked are alcohol abstinence and adequate optimization of nutrition to improve outcomes. In select patients, early liver transplantation may be an option or enrollment in clinical trials.
酒精相关性肝炎与不良预后相关，尤其是重度酒精相关性肝炎。尽管对大量潜在治疗药物进行了广泛研究，但治疗选择仍然有限，目前的标准治疗方法是皮质类固醇。粒细胞集落刺激因子是一种有前途的替代药物，尽管在更具异质性的患者群体中进一步研究之前，需要谨慎使用。经常被忽视的治疗辅助手段是戒酒和充分优化营养以改善预后。在某些患者中，早期肝移植可能是一种选择，或者参加临床试验。
