酒精性肝炎肝移植的当前趋势

Current Trends in Liver Transplantation for Alcoholic Hepatitis.

作者信息

Bhatti Sundus, Kim Donghee, Ahmed Aijaz, Cholankeril George

机构信息

Baylor College of Medicine, Section of Gastroenterology and Hepatology, 6620 Main Street, Suite 1450, Houston, TX 77030, USA; Baylor College of Medicine, Division of Abdominal Transplantation, Houston, TX, USA.

Stanford University School of Medicine, Division of Gastroenterology and Hepatology, 750 Welch Road, #210, Stanford, CA 94304, USA.

出版信息

Clin Liver Dis. 2021 Aug;25(3):625-634. doi: 10.1016/j.cld.2021.04.002. Epub 2021 May 29.

DOI:10.1016/j.cld.2021.04.002

PMID:34229844

Abstract

Liver transplantation (LT) for alcohol-related or alcoholic hepatitis (AH) remains a controversial treatment option. However, recent studies have shown promising outcomes for LT in a subgroup of patients with AH. Considering these emerging data, LT as definitive therapy for severe AH refractory to medical management is gaining recognition. However, concerns of alcohol recidivism pose a significant barrier to perform LT for this indication. Predictive models can be utilized to develop a selection criterion to identify suitable candidates for LT. Hence, carefully selected patients with severe AH and low risk of alcohol relapse can be considered for LT.

摘要

用于酒精相关性或酒精性肝炎（AH）的肝移植（LT）仍然是一种存在争议的治疗选择。然而，最近的研究表明，在一部分AH患者中，LT取得了令人鼓舞的结果。考虑到这些新出现的数据，将LT作为对药物治疗无效的重度AH的确定性治疗方法正逐渐得到认可。然而，对酒精复饮的担忧成为了针对这一适应症进行LT的重大障碍。可以利用预测模型来制定选择标准，以识别适合LT的候选人。因此，对于经过精心挑选的重度AH且酒精复发风险低的患者，可以考虑进行LT。